Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation Of Optic Disc, Retinal Vascular Structures And Acircularity Index In Patients With Idiopathic Macular Telangiectasia Type 2

Muhammet Kazim Erol
* ORCID logo ,
Birumut Gedik
ORCID logo ,
Yigit Caglar Bozdogan
,
Rojbin Ekinci
,
Mehmet Bulut
,
Berna Dogan
,
Elcin Suren
,
Melih Akidan
Version 1 : Received: 30 August 2023 / Approved: 31 August 2023 / Online: 1 September 2023 (03:37:18 CEST)

A peer-reviewed article of this Preprint also exists.

Erol, M.K.; Gedik, B.; Bozdogan, Y.C.; Ekinci, R.; Bulut, M.; Dogan, B.; Suren, E.; Akidan, M. Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2. Diagnostics 2023, 13, 3046. Erol, M.K.; Gedik, B.; Bozdogan, Y.C.; Ekinci, R.; Bulut, M.; Dogan, B.; Suren, E.; Akidan, M. Evaluation of Optic Disc, Retinal Vascular Structures, and Acircularity Index in Patients with Idiopathic Macular Telangiectasia Type 2. Diagnostics 2023, 13, 3046.

Abstract

Background We aimed to compare the retinal, optic disc vascular density (ODVD) values, and acircularity index (AI) of patients with idiopathic macular telangiectasia type 2 (IMT) and healthy individuals using the optical coherence tomography angiography(OCTA) device. Methods The study included 39 patients with IMT and 37 healthy controls. The OCTA findings of the patients and controls were examined. Results The total, parafoveal and perifoveal vascular density of the superficial capillary plexus, choriocapillaris blood flow, inside-disc ODVD, retinal nerve fiber layer (RNFL), and retinal thicknesses were found to be statistically significantly lower and the foveal avascular zone value was statistically significantly higher in the IMT group compared to the control group (p=0.001, p=0.01, p=0.02, p=0.01, p=0.009, p=0.002, p=0.02, respectively).There was a statistically significant negative correlation between best-corrected visual acuity (BCVA) and AI (p=0.02), a statistically significant positive correlation between peripapillary vascular density and BCVA(p=0.04). Conclusion We consider that the lower retinal, choriocapillaris, and ODVD values, retinal and RNFL thicknesses in the patients with IMT compared to the controls were due to vascular damage, remodeling, fibrosis, proliferation, and Müller cell damage. Ellipsoid zone defect, AI, and peripapillary vascular density are important indicators in the evaluation of visual acuity in these patients.

Keywords

Acircularity index; idiopathic macular telangiectasia type 2; optical coherence tomography angiography; optic disc vascular density; retinal vascular density

Subject

Medicine and Pharmacology, Ophthalmology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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