Yan, X.-Y.; Zhang, L.; Yang, Q.-B.; Ge, Z.-Y.; Liang, L.-F.; Guo, Y.-W. Genus Litophyton: A Hidden Treasure Trove of Structurally Unique and Diversely Bioactive Secondary Metabolites. Mar. Drugs2023, 21, 523.
Yan, X.-Y.; Zhang, L.; Yang, Q.-B.; Ge, Z.-Y.; Liang, L.-F.; Guo, Y.-W. Genus Litophyton: A Hidden Treasure Trove of Structurally Unique and Diversely Bioactive Secondary Metabolites. Mar. Drugs 2023, 21, 523.
Yan, X.-Y.; Zhang, L.; Yang, Q.-B.; Ge, Z.-Y.; Liang, L.-F.; Guo, Y.-W. Genus Litophyton: A Hidden Treasure Trove of Structurally Unique and Diversely Bioactive Secondary Metabolites. Mar. Drugs2023, 21, 523.
Yan, X.-Y.; Zhang, L.; Yang, Q.-B.; Ge, Z.-Y.; Liang, L.-F.; Guo, Y.-W. Genus Litophyton: A Hidden Treasure Trove of Structurally Unique and Diversely Bioactive Secondary Metabolites. Mar. Drugs 2023, 21, 523.
Abstract
Marine soft corals are prolific sources of various natural products that have served as a wealthy reservoir of diverse chemical scaffolds for new drug leads. The genus Litophyton contains almost 100 species but only a small part of them had been classified and chemically investigated, which calls for more attentions from the global researchers. In the current work, 109 secondary metabolites have been discussed based on published data from 1975 to July, 2023, covering a period of near five decades. The studied species of the genus Litophyton inhabited various tropical and temperate regions and afforded a variety of biologically active natural products such as terpenes, steroids, alkaloids, and lipids. A wide spectrum of pharmacological effects of these compounds had been evaluated, including cytotoxic, anti-HIV, antibacterial, antifungal, anti-malarial, antifeedant, molluscicidal, PTP1B inhibitory, and insect growth inhibitory activities. This review aims to provide an up-to-date literature survey and comprehensive insight into chemical structures, taxonomical distributions, and biological activities of the reported metabolites from the title genus whenever available.
Chemistry and Materials Science, Medicinal Chemistry
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