Dragomanova, S.; Andonova, V.; Volcho, K.; Salakhutdinov, N.; Kalfin, R.; Tancheva, L. Therapeutic Potential of Myrtenal and Its Derivatives—A Review. Life2023, 13, 2086.
Dragomanova, S.; Andonova, V.; Volcho, K.; Salakhutdinov, N.; Kalfin, R.; Tancheva, L. Therapeutic Potential of Myrtenal and Its Derivatives—A Review. Life 2023, 13, 2086.
Dragomanova, S.; Andonova, V.; Volcho, K.; Salakhutdinov, N.; Kalfin, R.; Tancheva, L. Therapeutic Potential of Myrtenal and Its Derivatives—A Review. Life2023, 13, 2086.
Dragomanova, S.; Andonova, V.; Volcho, K.; Salakhutdinov, N.; Kalfin, R.; Tancheva, L. Therapeutic Potential of Myrtenal and Its Derivatives—A Review. Life 2023, 13, 2086.
Abstract
Monoterpenes as natural products are the subject of increased attention in the search for new pharmacological agents because of their numerous biological activities including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, vasodilating effects, etc. In vitro and in vivo studies reveal their antidepressant, anxiolytic, and memory-enhancing in experimental dementia and Parkinson’s disease effects. Chemical modification of natural substances by conjugation with various synthetic components is a modern method of obtaining new biologically active compounds. The discovery of new potential drugs among monoterpene derivatives is a progressive direction in experimental pharmacology and a promising approach to the therapy of various pathologies. Biologically active substances such as monoterpenes borneol, camphor, geraniol, pinene, and thymol, were used to synthesize compounds with different properties, including analgesic, anti-inflammatory, anticonvulsant, anti-depressant, anti-Alzheimer’s, anti-parkinsonian, antiviral and antibacterial (anti-tuberculosis). Myrtenal is a perspective monoterpenoid with therapeutic potential in various fields of medicine. Its chemical modifications often lead to new or more pronounced biological effects. As an example, conjugation of myrtenal with the known pharmacophore adamantane allows one to enhance some of its key properties. Myrtenal-adamantane derivatives exhibited a variety of beneficial properties – antimicrobial, antifungal, antiviral, anticancer, anxiolytic, and neuroprotective, which are worth examining in more detail and at length.
Keywords
monoterpene; pharmacophore; chemical modification; antiviral; anticancer; anxiolytic; neuroprotective activity
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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