Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Barriers to Antiretroviral Medication Adherence in People Living with HIV (PLHIV) at the time of COVID-19 Pandemic in the Philippines

Version 1 : Received: 29 August 2023 / Approved: 29 August 2023 / Online: 30 August 2023 (09:45:38 CEST)

A peer-reviewed article of this Preprint also exists.

Joves, P.J.M.; Matulac, M.O.; Pagcatipunan, R.S., Jr. Barriers to Antiretroviral Medication Adherence in People Living with HIV (PLHIV) at the Time of the COVID-19 Pandemic in the Philippines. Trop. Med. Infect. Dis. 2023, 8, 461. Joves, P.J.M.; Matulac, M.O.; Pagcatipunan, R.S., Jr. Barriers to Antiretroviral Medication Adherence in People Living with HIV (PLHIV) at the Time of the COVID-19 Pandemic in the Philippines. Trop. Med. Infect. Dis. 2023, 8, 461.

Abstract

I. Introduction: Adherence to ART reduces morbidity and mortality among PLHIV by suppression of viral replication, restoration and preservation of immune function. However, poor adherence may lead to treatment failure and death. PLHIV have high probability of treatment interruptions due to lockdowns related to COVID-19 protocol. Mortality rate is higher among COVID-19 patients with HIV than those with COVID-19 only. This led to determination of the barriers to antiretroviral medication adherence in PLHIV at the time of COVID-19 pandemic and seek significant association between identified HIV treatment barriers and socio-demographic characteristics. II. Methods: A cross-sectional study using online survey questionnaire was distributed via social media. Sample size was computed using Open Epi software. Data was analyzed using Stata software. Categorical variables and quantitative data were summarized using frequencies and percentages, and mean and standard deviation respectively. Chi-square test or Fisher’s exact test, whichever is more appropriate, was used to determine association between socio-demographic characteristics and HIV treatment barriers. III. Results: There is a total of 116 respondents, 115 were males, homosexual (59.5%), with mean age of 30.25 years old (SD = 6.22) and majority (53.4%) were from NCR. The most common HIV treatment barriers reported by PLHIV in accessing treatment and care were unavailability of transportation and cost of courier services for ARV delivery (62.1%), location of treatment hubs (52.6%) and financial assistance (37.9%). IV. Conclusion: There is significant association between location of treatment hubs and respondents who finished college/graduate studies; checkpoints and crossing borders and: 1. respondents from Northern Luzon, 2. unemployment; financial assistance and: 1. Respondents 18 to 25 years old, 2. unemployment, 3. respondents who finished elementary/high school; psychosocial support and: 1. Respondents from NCR, 2. Respondents 26 to 30 years old;

Keywords

HIV; AIDS; antiretroviral therapy; COVID19; public health; medication adherence

Subject

Public Health and Healthcare, Public Health and Health Services

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