Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cavitating Lesions Around the Cochlea Can Affect Audiometric Threshold and Clinical Practice

Version 1 : Received: 23 August 2023 / Approved: 24 August 2023 / Online: 25 August 2023 (04:57:24 CEST)

A peer-reviewed article of this Preprint also exists.

Zambonini, G.; Ghiselli, S.; Di Trapani, G.; Salsi, D.; Cuda, D. Cavitating Lesions around the Cochlea Can Affect Audiometric Threshold and Clinical Practice. Audiol. Res. 2023, 13, 821-832. Zambonini, G.; Ghiselli, S.; Di Trapani, G.; Salsi, D.; Cuda, D. Cavitating Lesions around the Cochlea Can Affect Audiometric Threshold and Clinical Practice. Audiol. Res. 2023, 13, 821-832.

Abstract

There are several pathologies that can change the anatomy of the otic capsule and that can distort the bone density of the bony structures of the inner ear, but otosclerosis is one of the most frequent. Similar behavior has been shown in patients affected by osteogenesis imperfecta (OI), a genetic disease due to a mutation in the genes coding for type I (pro) collagen. In particular, we note that otosclerosis and OI can lead to bone resorption creating pericochlear cavitations in contact with the internal auditory canal (IAC). In this regard, in our experience we have collected 5 cases presenting this characteristic and their audiological data and clinical history were analyzed. This feature can be defined as a potential cause of a third-window effect, because it causes an energy loss during the transmission of sound waves from the OW away from the basilar membrane.

Keywords

third window effect; otosclerosis; osteogenesis imperfecta; cavitating otosclerosis; cavitating osteogenesis imperfecta; pseudo-CHL; internal auditory canal diverticulum; double ring effect; cochlear implant

Subject

Medicine and Pharmacology, Otolaryngology

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