Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Designing an In Vivo Preclinical Research Study

Angel Moctezuma Ramirez
ORCID logo ,
David Dworaczyk
,
Julia Whitehorn
,
Ke Li
,
Cristiano de Oliveira Cardoso
,
Abdelmotagaly Elgalad
* ORCID logo
Version 1 : Received: 22 August 2023 / Approved: 23 August 2023 / Online: 24 August 2023 (08:11:01 CEST)

A peer-reviewed article of this Preprint also exists.

Moctezuma-Ramirez, A.; Dworaczyk, D.; Whitehorn, J.; Li, K.; Cardoso, C.O.; Elgalad, A. Designing an In Vivo Preclinical Research Study. Surgeries 2023, 4, 544-555. Moctezuma-Ramirez, A.; Dworaczyk, D.; Whitehorn, J.; Li, K.; Cardoso, C.O.; Elgalad, A. Designing an In Vivo Preclinical Research Study. Surgeries 2023, 4, 544-555.

Abstract

During the preclinical research process, multiple factors can be difficult to implement without the careful consideration and planning of each step. As research has become more advanced with the use of increasingly complex technology, animal models have also become essential for understanding the potential impact of devices, drug therapies, and surgical techniques on humans before clinical trials are conducted. The use of an in vivo animal model is a key and necessary step in the progression of preclinical research studies that will lead to future medical inventions and innovation. Here, we describe the three phases of effectively designing a preclinical research protocol: the research, preprocedural planning, and experimental phases. Furthermore, we provide researchers with guidance through these phases and discuss important considerations.

Keywords

in vivo; exploratory; confirmatory; preclinical research; preprocedural planning; animal model; study endpoints; pitfalls

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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