Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

New Prognostic Index for Neoadjuvant Chemotherapy Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer

Chuying Huo
# ,
Bin Wu
# ,
Dongdong Ye
# ,
Miaochun Xu
,
Shaolin Ma
ORCID logo ,
Aoshuang Cheng
,
Yunyun Liu
,
Chunxian Huang
,
Yuhao Zhang
,
Zhongqiu Lin
,
Xinyuan Lei
* ,
Bowen Li
* ,
Huaiwu Lu
*
#
These authors contributed equally.
Version 1 : Received: 20 August 2023 / Approved: 21 August 2023 / Online: 22 August 2023 (07:31:01 CEST)

How to cite: Huo, C.; Wu, B.; Ye, D.; Xu, M.; Ma, S.; Cheng, A.; Liu, Y.; Huang, C.; Zhang, Y.; Lin, Z.; Lei, X.; Li, B.; Lu, H. New Prognostic Index for Neoadjuvant Chemotherapy Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer. Preprints 2023, 2023081527. https://doi.org/10.20944/preprints202308.1527.v1 Huo, C.; Wu, B.; Ye, D.; Xu, M.; Ma, S.; Cheng, A.; Liu, Y.; Huang, C.; Zhang, Y.; Lin, Z.; Lei, X.; Li, B.; Lu, H. New Prognostic Index for Neoadjuvant Chemotherapy Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer. Preprints 2023, 2023081527. https://doi.org/10.20944/preprints202308.1527.v1

Abstract

Background: A prognostic index validated for the outcomes of advanced high-grade serous ovarian cancer (HGSOC) patients with neoadjuvant chemotherapy (NACT) is still lacking. We therefore developed an ovarian neoadjuvant chemotherapy prognostic index (ONCPI) to enhance predictive accuracy. Methods: We analyzed clinicopathologic feature of advanced HGSOC patients receiving platinum-based NACT. Blood inflammatory composite markers were calculated and binary-transformed by optimal cutoffs. The omental hematoxylin and eosin (H&E) stained slides were selected for the assessment of chemotherapy response score (CRS). Logistic regression analyses and Cox proportional hazard regression model were utilized to develop a prognostic index. Results: Multivariate analysis showed that CRS and neutrophils-to-lymphocyte ratio (NLR) are independent risk factors for platinum-chemotherapy response. Meanwhile, Kaplan–Meier and Cox regression analysis revealed that CRS score was significantly correlated with PFS and OS, and NLR-high patients was associated with poor OS. We further developed an ONCPI model based on the CRS score and NLR level. Survival analysis suggested that patients with score 0 and 1 of ONCPI were significantly associated with improved PFS and OS. Conclusions: The ONCPI score emerges as a significant prognostic marker for predicting NACT outcomes in advanced HGSOC patients. Its integration into clinical practice and risk-stratified trial design is conceivable.

Keywords

high grade serous ovarian cancer; neoadjuvant chemotherapy; prognostic index

Subject

Arts and Humanities, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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