Stępnik, K.; Kukula-Koch, W.; Boguszewska-Czubara, A.; Gawel, K. Astragaloside IV as a Memory-Enhancing Agent: In Silico Studies with In Vivo Analysis and Post Mortem ADME-Tox Profiling in Mice. Int. J. Mol. Sci.2024, 25, 4021.
Stępnik, K.; Kukula-Koch, W.; Boguszewska-Czubara, A.; Gawel, K. Astragaloside IV as a Memory-Enhancing Agent: In Silico Studies with In Vivo Analysis and Post Mortem ADME-Tox Profiling in Mice. Int. J. Mol. Sci. 2024, 25, 4021.
Stępnik, K.; Kukula-Koch, W.; Boguszewska-Czubara, A.; Gawel, K. Astragaloside IV as a Memory-Enhancing Agent: In Silico Studies with In Vivo Analysis and Post Mortem ADME-Tox Profiling in Mice. Int. J. Mol. Sci.2024, 25, 4021.
Stępnik, K.; Kukula-Koch, W.; Boguszewska-Czubara, A.; Gawel, K. Astragaloside IV as a Memory-Enhancing Agent: In Silico Studies with In Vivo Analysis and Post Mortem ADME-Tox Profiling in Mice. Int. J. Mol. Sci. 2024, 25, 4021.
Abstract
Astragaloside IV (AIV) – triterpenoid saponin from the Astragalus mongholicus roots with the proved acetylcholinesterase (AChE)-inhibitory capability was used as the substance with the potential to attenuate memory impairment. Scopolamine (SCOP), antagonist of muscarinic cholinergic receptors and lipopolysaccharide (LPS), neuroinflammation inducer were used to impair memory processes in the passive avoidance (PA) test in mice. This memory impairment in the SCOP-treated mice was attenuated by the earlier intraperitoneal (ip) administration of AIV in the dose of 25 mg/kg. The reduction of memory impairment by LPS was not observed, therefore AIV does not reverse memory impairments through the anti-inflammatory mechanisms. All the studied doses of AIV did not affect basic locomotor activity of mice. As a result of the post-mortem analysis of mice body tissues, the largest content of AIV was determined in the kidneys, then in the spleen, liver and the smallest one in brain by mass spectrometry.
Chemistry and Materials Science, Medicinal Chemistry
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