Akgün Karapınar, B.; Çaklovica Küçükkaya, İ.; Bölükbaşı, Y.; Küçükkaya, S.; Erköse Genç, G.; Erturan, Z.; Ağaçfidan, A.; Öngen, B. Evaluation of Blood Cultures from SARS-CoV-2-Positive and Negative Adult Patients. Healthcare2023, 11, 2581.
Akgün Karapınar, B.; Çaklovica Küçükkaya, İ.; Bölükbaşı, Y.; Küçükkaya, S.; Erköse Genç, G.; Erturan, Z.; Ağaçfidan, A.; Öngen, B. Evaluation of Blood Cultures from SARS-CoV-2-Positive and Negative Adult Patients. Healthcare 2023, 11, 2581.
Akgün Karapınar, B.; Çaklovica Küçükkaya, İ.; Bölükbaşı, Y.; Küçükkaya, S.; Erköse Genç, G.; Erturan, Z.; Ağaçfidan, A.; Öngen, B. Evaluation of Blood Cultures from SARS-CoV-2-Positive and Negative Adult Patients. Healthcare2023, 11, 2581.
Akgün Karapınar, B.; Çaklovica Küçükkaya, İ.; Bölükbaşı, Y.; Küçükkaya, S.; Erköse Genç, G.; Erturan, Z.; Ağaçfidan, A.; Öngen, B. Evaluation of Blood Cultures from SARS-CoV-2-Positive and Negative Adult Patients. Healthcare 2023, 11, 2581.
Abstract
Bacteremia and fungemia are significant causes of morbidity and mortality which frequently occur as co-infections with viral respiratory infections including SARS-CoV-2. It was aimed to evaluate the microorganisms isolated from blood cultures of SARS-CoV-2 positive and negative patients and investigate their antimicrobial resistance patterns. A retrospective analysis was performed with the total number of 22,944 blood cultures sent to the laboratory between November 2020 and December 2021. Blood cultures were performed on the BD Bactec automated system. Identification was performed using conventional methods, VITEK-2 and MALDI-TOF MS. Antibacterial/antifungal susceptibility tests were performed according to EUCAST/CLSI recommendations. SARS-CoV-2 tests were performed with RT-PCR. It was detected 1,630 culture positivity belonging to 652 patients. Totally 633 of 652 patients were tested for SARS-CoV-2; 118 (18.6%) were positive and 515 (81.3%) were negative. The bacteria and fungi isolated at the high-est rate in SARS-CoV-2 positive patients were methicillin-resistant coagulase negative staphylococci (MR-CoNS) (21.5%), Escherichia coli (12.4%), Klebsiella pneumoniae (12.4%), Candida albicans (1.65%) and Candida glabrata complex (1.65%); while in negative patients, E. coli (21.3%), MR-CoNS (13.5%), K. pneumoniae (12.05%), C. albicans (2.1%), Candida parapsilosis (1.1%) and Candida tropicalis (0.9%). The fact that the most common isolate was MR-CoNS in SARS-CoV-2 positive patients (p = 0.028); the detection of Acinetobacter baumannii was more frequent (p = 0.001) and the isolation of carbapenem-resistant K. pneumoniae was at a higher rate than in SARS-CoV-2 negative patients; also, the increase in multidrug-resistant strains indicate that healthcare-associated infec-tions should not be disregarded while focusing on the outbreak.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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