Version 1
: Received: 16 August 2023 / Approved: 16 August 2023 / Online: 17 August 2023 (09:32:50 CEST)
How to cite:
Abdalla, D.M.; Abdalla, E.M.; Almekkawi, A.K.; Ahmed, R.E.; Minasian, T.; El Ahmadieh, T.Y. The Use of Circulating Tumor DNA Assays and Liquid Biopsies in Pediatric Brain Tumors: A Review. Preprints2023, 2023081250. https://doi.org/10.20944/preprints202308.1250.v1
Abdalla, D.M.; Abdalla, E.M.; Almekkawi, A.K.; Ahmed, R.E.; Minasian, T.; El Ahmadieh, T.Y. The Use of Circulating Tumor DNA Assays and Liquid Biopsies in Pediatric Brain Tumors: A Review. Preprints 2023, 2023081250. https://doi.org/10.20944/preprints202308.1250.v1
Abdalla, D.M.; Abdalla, E.M.; Almekkawi, A.K.; Ahmed, R.E.; Minasian, T.; El Ahmadieh, T.Y. The Use of Circulating Tumor DNA Assays and Liquid Biopsies in Pediatric Brain Tumors: A Review. Preprints2023, 2023081250. https://doi.org/10.20944/preprints202308.1250.v1
APA Style
Abdalla, D.M., Abdalla, E.M., Almekkawi, A.K., Ahmed, R.E., Minasian, T., & El Ahmadieh, T.Y. (2023). The Use of Circulating Tumor DNA Assays and Liquid Biopsies in Pediatric Brain Tumors: A Review. Preprints. https://doi.org/10.20944/preprints202308.1250.v1
Chicago/Turabian Style
Abdalla, D.M., Tanya Minasian and Tarek Y. El Ahmadieh. 2023 "The Use of Circulating Tumor DNA Assays and Liquid Biopsies in Pediatric Brain Tumors: A Review" Preprints. https://doi.org/10.20944/preprints202308.1250.v1
Abstract
Pediatric brain tumors are the leading cause of cancer-related death in children. Diagnosis cur-rently relies on surgical biopsy to obtain tumor tissue for histological analysis. There is a great need for less invasive approaches to molecularly profile tumors and monitor therapeutic response. Liquid biopsy analysis of circulating tumor biomarkers in biofluids like cerebrospinal fluid (CSF) and blood offers a promising minimally invasive strategy. This review discusses recent advances in developing liquid biopsy assays using next-generation sequencing, digital PCR, and emerging techniques to detect circulating tumor DNA (ctDNA), cells (CTCs), and exosomes in pediatric brain tumors. The ability to use these circulating biomarkers for non-invasive diagnosis, thera-peutic targeting, tracking response to therapy, and understanding resistance mechanisms is ex-amined. Technical and clinical validation challenges to translate liquid biopsies into routine clin-ical practice are also discussed.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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