Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Febrile Seizure in Infants Underlies Endophenotypes of Autism Spectrum Disorder in Rats

Yeon Hee Yu
ORCID logo ,
Seong-Wook Kim
,
Hyuna Im
,
Yu Ran Lee
,
Gun Woo Kim
,
Seongho Ryu
,
Dae-Kyoon Park
* ORCID logo ,
Duk-Soo Kim
* ORCID logo
Version 1 : Received: 9 August 2023 / Approved: 9 August 2023 / Online: 10 August 2023 (10:44:26 CEST)

A peer-reviewed article of this Preprint also exists.

Yu, Y.H.; Kim, S.-W.; Im, H.; Lee, Y.R.; Kim, G.W.; Ryu, S.; Park, D.-K.; Kim, D.-S. Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats. Cells 2023, 12, 2446. Yu, Y.H.; Kim, S.-W.; Im, H.; Lee, Y.R.; Kim, G.W.; Ryu, S.; Park, D.-K.; Kim, D.-S. Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats. Cells 2023, 12, 2446.

Abstract

Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms including impaired social behaviors; however, no causative link between FS and autism spectrum disorder (ASD) has yet been established. Here, we provide evidence linking FS occurrence with ASD pathogenesis in rats. We developed an FS juvenile rats model and found ASD-like abnormal behaviors including deficits in social novelty, repetitive behaviors, and hyperlocomotion. In addition, FS model juvenile rats showed enhanced levels of gliosis and inflammation in the hippocampal CA2 region and cerebellum. Furthermore, abnormal levels of social and repetitive behaviors persisted in adults FS model rats. These findings suggest that occurrence of FS in infants can cause behavioral endophenotypes of ASD.

Keywords

febrile seizure; autism spectrum disorder; CA2 region; inflammation; gliosis

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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