Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Multicentric Study from Southern Italy Hospitals on Oncological Outcomes and Prognostic Factors of Open Partial Horizontal Laryngectomies (OPHL) for Laryngeal Cancer

Eugenia Allegra
* ORCID logo ,
Maria Rita Bianco
* ,
Domenico Michele Modica
ORCID logo ,
Alfio Azzolina
,
Elio Privitera
ORCID logo ,
Daniele Latella
,
Federico Occhiuzzi
,
Mario Galfano
,
Vincenzo Saita
Version 1 : Received: 6 August 2023 / Approved: 7 August 2023 / Online: 8 August 2023 (10:25:24 CEST)

How to cite: Allegra, E.; Bianco, M.R.; Modica, D.M.; Azzolina, A.; Privitera, E.; Latella, D.; Occhiuzzi, F.; Galfano, M.; Saita, V. Multicentric Study from Southern Italy Hospitals on Oncological Outcomes and Prognostic Factors of Open Partial Horizontal Laryngectomies (OPHL) for Laryngeal Cancer. Preprints 2023, 2023080627. https://doi.org/10.20944/preprints202308.0627.v1 Allegra, E.; Bianco, M.R.; Modica, D.M.; Azzolina, A.; Privitera, E.; Latella, D.; Occhiuzzi, F.; Galfano, M.; Saita, V. Multicentric Study from Southern Italy Hospitals on Oncological Outcomes and Prognostic Factors of Open Partial Horizontal Laryngectomies (OPHL) for Laryngeal Cancer. Preprints 2023, 2023080627. https://doi.org/10.20944/preprints202308.0627.v1

Abstract

In recent years, the number of open preservation surgeries for treatment of laryngeal Cancer has increased. The purpose of this surgery is to avoid the highly mutilating intervention of a total laryngectomy (TL) and to maintain laryngeal function while ensuring oncological radicality. The aim of this study was to assess the oncologic results of OPHL I and II and to identify prognostic factors that could impact patient survival and local failure rates. This study was conducted on 182 patients with laryngeal squamous cell carcinoma treated with OPHLs between 2005 and 2015. The survival rates of a group of patients treated with TL between 2004 and 2014 were taken into con-sideration to compare survival outcomes. The DSS in pT2 and pT3 tumors in relation to the type of surgery showed no statistically significant difference between OPHLs and TL (p=0.54 and p=0.63 respectively). The 5-years T-recurrence free survival showed that pT4 tumors, perineural/vascular positive invasion and OPHL IIb + ARY treated tumors were associated with a higher risk of tumor recurrence (p<0.0001, p=0.0005 and p=0.016 respectively). OPHLs represent an excellent alterna-tive to TL considering the characteristics of the tumor and the general conditions of the patient.

Keywords

open partial horizontal laryngectomy; laryngeal cancer; laryngeal preservation; laryngectomy free survival; disease specific survival; total laryngectomy

Subject

Medicine and Pharmacology, Otolaryngology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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