Version 1
: Received: 4 August 2023 / Approved: 7 August 2023 / Online: 8 August 2023 (02:49:33 CEST)
How to cite:
Bazsó, A.; Kiss, E. The Role of Biomarkers in the Pathogenesis, Clinical Manifestations, and Therapeutic Approach in Systemic Sclerosis. Preprints2023, 2023080557. https://doi.org/10.20944/preprints202308.0557.v1
Bazsó, A.; Kiss, E. The Role of Biomarkers in the Pathogenesis, Clinical Manifestations, and Therapeutic Approach in Systemic Sclerosis. Preprints 2023, 2023080557. https://doi.org/10.20944/preprints202308.0557.v1
Bazsó, A.; Kiss, E. The Role of Biomarkers in the Pathogenesis, Clinical Manifestations, and Therapeutic Approach in Systemic Sclerosis. Preprints2023, 2023080557. https://doi.org/10.20944/preprints202308.0557.v1
APA Style
Bazsó, A., & Kiss, E. (2023). The Role of Biomarkers in the Pathogenesis, Clinical Manifestations, and Therapeutic Approach in Systemic Sclerosis. Preprints. https://doi.org/10.20944/preprints202308.0557.v1
Chicago/Turabian Style
Bazsó, A. and Emese Kiss. 2023 "The Role of Biomarkers in the Pathogenesis, Clinical Manifestations, and Therapeutic Approach in Systemic Sclerosis" Preprints. https://doi.org/10.20944/preprints202308.0557.v1
Abstract
Systemic sclerosis (SSc) is a progressive autoimmune disorder that mainly affects the skin. There are other clinical manifestations as renal, pulmonary, cardiovascular, and gastrointestinal tract involvements. Based on the skin involvement there are two subtypes of SSc, as limited cutaneous SSc (lSSc) which involves the acral part of the body and diffuse cutaneous SSc (dSSc) resulting in significant skin thickening of the body. The lSSc has usually moderate internal organ manifestations, except for the late-onset pulmonary arterial hypertension (PAH) mainly appearing in this form. In dSSc the severity of the organ manifestations or failure is more intensive such as scleroderma renal crisis (RSC), interstitial lung disease (ILD), myocardial fibrosis, and chronic gastrointestinal dysmotility with consequent malabsorption
Keywords
systemic sclerosis; organ manifestations; biomarkers; prognosis
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
