Bertoni, C.; Abodi, M.; D’Oria, V.; Milani, G.P.; Agostoni, C.; Mazzocchi, A. Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review. Int. J. Mol. Sci.2023, 24, 14319.
Bertoni, C.; Abodi, M.; D’Oria, V.; Milani, G.P.; Agostoni, C.; Mazzocchi, A. Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review. Int. J. Mol. Sci. 2023, 24, 14319.
Bertoni, C.; Abodi, M.; D’Oria, V.; Milani, G.P.; Agostoni, C.; Mazzocchi, A. Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review. Int. J. Mol. Sci.2023, 24, 14319.
Bertoni, C.; Abodi, M.; D’Oria, V.; Milani, G.P.; Agostoni, C.; Mazzocchi, A. Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review. Int. J. Mol. Sci. 2023, 24, 14319.
Abstract
Cardiovascular diseases (CVDs) represent the leading cause of global mortality with 1,7 million deaths a year. One of the alternative systems to drug therapy to minimize the risk of CVDs is represented by alpha-linolenic acid (ALA), an essential fatty acid of the Omega-3 series, known for its cholesterol-lowering effect. The main purpose of this review is to analyze the effects of ALA and investigate the relevant n-6/n-3 ratio in order to maintain functionally beneficial effects. Concerning the lipid-lowering preventive effects, ALA may favorably affect the values of LDL-C and triglycerides in either adult and pediatric populations and it has a positive and protective effect against hypertension, suggesting that ALA is an useful diet-related antihypertensive compound. According to the 2009 EFSA statement, dietary ALA may contribute to reducing the risk of CVDs, thanks to anti-hypertensive, anti-atherosclerotic and cardio-protective effects.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
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