Review
Version 1
Preserved in Portico This version is not peer-reviewed
Bimetallic (or Multimetallic) Synthesis of N-Heterocycles
Version 1
: Received: 2 August 2023 / Approved: 3 August 2023 / Online: 4 August 2023 (14:50:41 CEST)
A peer-reviewed article of this Preprint also exists.
Reis, A.R.; Viduedo, N.; Raydan, D.; Marques, M.M.B. Bimetallic (or Multimetallic) Synthesis of N-Heterocycles. Catalysts 2023, 13, 1268. Reis, A.R.; Viduedo, N.; Raydan, D.; Marques, M.M.B. Bimetallic (or Multimetallic) Synthesis of N-Heterocycles. Catalysts 2023, 13, 1268.
Abstract
Bimetallic (or multimetallic) catalysis has emerged as a powerful tool in modern chemical synthesis, offering improved reaction control and versatility. This review focuses on the recent de-velopments in bimetallic sequential catalysis for the synthesis of nitrogen heterocycles, essential building blocks in pharmaceuticals and fine chemicals. The cooperative action of two (and sometimes more) different metal catalysts enables intricate control over reaction pathways, enhancing selectivity and efficiency of N-heterocyclic compounds synthesis. By activating less reactive substrates, this multimetal catalytic strategy opens new synthetic possibilities for challenging compounds. The use of catalytic materials in bimetallic systems reduces waste and improves atom efficiency, aligning with green chemistry principles. With a diverse range of metal combinations and reaction conditions, bimetallic catalysis provides access to a broad array of N-heterocyclic compounds with various functionalities. This paper highlights the significant progress made in the past decade in this topic, emphasizing the promising potential of bimetallic catalysis in drug discovery and the fine chemical industries.
Keywords
Bimetallic catalysis; multimetallic catalysis; sequential catalysis; N-heterocycles; transition metals; green chemistry
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
