Khandker, S.S.; Jannat, N.; Sarkar, D.; Pranto, A.H.; Hoque, I.A.; Zaman, J.; Uddin, M.N.; Suez, E. Association between Glomerular Filtration Rate and β-Thalassemia Major: A Systematic Review and Meta-Analysis. Thalass. Rep.2023, 13, 195-205.
Khandker, S.S.; Jannat, N.; Sarkar, D.; Pranto, A.H.; Hoque, I.A.; Zaman, J.; Uddin, M.N.; Suez, E. Association between Glomerular Filtration Rate and β-Thalassemia Major: A Systematic Review and Meta-Analysis. Thalass. Rep. 2023, 13, 195-205.
Khandker, S.S.; Jannat, N.; Sarkar, D.; Pranto, A.H.; Hoque, I.A.; Zaman, J.; Uddin, M.N.; Suez, E. Association between Glomerular Filtration Rate and β-Thalassemia Major: A Systematic Review and Meta-Analysis. Thalass. Rep.2023, 13, 195-205.
Khandker, S.S.; Jannat, N.; Sarkar, D.; Pranto, A.H.; Hoque, I.A.; Zaman, J.; Uddin, M.N.; Suez, E. Association between Glomerular Filtration Rate and β-Thalassemia Major: A Systematic Review and Meta-Analysis. Thalass. Rep. 2023, 13, 195-205.
Abstract
Thalassemia is one of the most prevalent genetic disorders worldwide which has been previously found to have an association with several physiological and organ complications. Several studies found both its positive and inverse correlation with glomerular filtration rate (GFR). Therefore, in this meta-analysis, we tried to assess the accurate correlation of thalassemia with GFR. We searched in Google Scholar, PubMed, and ScienceDirect, and from the initial 96 articles we finally could include 15 studies. The quality and publication bias assessment confirmed that all the studies were of high to moderate quality with no publication bias. The main outcome of the mean difference (MD) was -6.45, 95%CI: -18.50, 5.60 (P<0.00001), which indicated a negative correlation of GFR with thalassemia. The sensitivity analyses found one study as a slight outlier and reanalyzing the data excluding that study MD was achieved as -13.90, 95%CI: -24.22, -3.59 (P<0.00001) which even strongly supports our main outcome. Our result determined that the GFR is generally higher in healthy people as compared to thalassemia patients.
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