Exploring the Efficacy of Hormone Replacement Therapy: A Network Meta-Analysis

Version 1 : Received: 27 July 2023 / Approved: 27 July 2023 / Online: 28 July 2023 (13:34:12 CEST)
Version 2 : Received: 28 July 2023 / Approved: 31 July 2023 / Online: 2 August 2023 (10:27:07 CEST)

How to cite: Delanerolle, G.; Taylor, J.; Yang, X.; Zou, R.; Bouchareb, Y.; Cavalini, H.; Jagadeesan, P.; Kurmi, O.; Riach, K.; Hinchcliff, S.; Atkinson, C.; Potočnik, K.; Briggs, P.; Talaulikar, V.; Saraswat, L.; Khazali, S.; Shi, J.Q.; Shetty, A.; Phiri, P. Exploring the Efficacy of Hormone Replacement Therapy: A Network Meta-Analysis. Preprints 2023, 2023071982. https://doi.org/10.20944/preprints202307.1982.v2 Delanerolle, G.; Taylor, J.; Yang, X.; Zou, R.; Bouchareb, Y.; Cavalini, H.; Jagadeesan, P.; Kurmi, O.; Riach, K.; Hinchcliff, S.; Atkinson, C.; Potočnik, K.; Briggs, P.; Talaulikar, V.; Saraswat, L.; Khazali, S.; Shi, J.Q.; Shetty, A.; Phiri, P. Exploring the Efficacy of Hormone Replacement Therapy: A Network Meta-Analysis. Preprints 2023, 2023071982. https://doi.org/10.20944/preprints202307.1982.v2

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MDPI and ACS Style

Delanerolle, G.; Taylor, J.; Yang, X.; Zou, R.; Bouchareb, Y.; Cavalini, H.; Jagadeesan, P.; Kurmi, O.; Riach, K.; Hinchcliff, S.; Atkinson, C.; Potočnik, K.; Briggs, P.; Talaulikar, V.; Saraswat, L.; Khazali, S.; Shi, J.Q.; Shetty, A.; Phiri, P. Exploring the Efficacy of Hormone Replacement Therapy: A Network Meta-Analysis. Preprints 2023, 2023071982. https://doi.org/10.20944/preprints202307.1982.v2

APA Style

Delanerolle, G., Taylor, J., Yang, X., Zou, R., Bouchareb, Y., Cavalini, H., Jagadeesan, P., Kurmi, O., Riach, K., Hinchcliff, S., Atkinson, C., Potočnik, K., Briggs, P., Talaulikar, V., Saraswat, L., Khazali, S., Shi, J.Q., Shetty, A., & Phiri, P. (2023). Exploring the Efficacy of Hormone Replacement Therapy: A Network Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202307.1982.v2

Chicago/Turabian Style

Delanerolle, G., Ashish Shetty and Peter Phiri. 2023 "Exploring the Efficacy of Hormone Replacement Therapy: A Network Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202307.1982.v2

Abstract

Purpose: Hormone Replacement Therapy (HRT), an FDA-approved treatment for menopausal conditions was found to be associated with increased risk of endometrial cancer and reduced oestrogen. Studies showing benefits of HRT in preventing chronic diseases lead to development of clinical guidelines by American College of Physicians. This study aims to assess effectiveness of HRT treatments across cardiometabolic measures including Triglycerides (TG), Follicle-Stimulating Hormone, LDL cholesterol, HDL cholesterol, and Estradiol in menopausal women. It reports gaps in scientific knowledge and clinical practice to enhance current guidelines and policies.Methods: A systematic methodology designed and published in PROSPERO (CRD42022346057) to report network meta-epidemiology analysis was utilised. We used databases by PubMed, Web of Science, ScienceDirect, EMBASE and MEDLINE for studies published between 30th of April 1980-2022. Effects of HRT treatments were explored using a mixed treatment comparison (MTC) model. Fixed and random-effects models were used to address heterogeneity in published studies. Publication bias was assessed and corrected using funnel plots and Egger’s test.Results: Of 45 eligible studies, our findings indicate a significant statistical heterogeneity between HRTs and reduction of TG, SFH, LDL-C alongside increase of HDL-C and Estradiol among menopausal women. The analysis suggests a lack of direct evidence to support their efficacy in reducing TG, SFH and LDL-C levels or to substantiate HRT’s effectiveness in increasing HDL-C and Estradiol. The results showed no significant publication bias in the meta-analysis of included studies.Conclusion: Our findings demonstrate that use of HRT interventions among menopausal women may reduce TG, FSH and LDL-C levels and increase levels of HDL-C and estradiol via oral and oral + transdermal administration. Our study reaffirms efficacy of HRT in supporting favourable lipid profile in menopausal women whilst highlighting the need for robust and inclusive epidemiology studies and clinical trials to further develop clinical guidelines and policies.

Keywords

Hormone replacement therapy; Menopause; Cardiovascular disease; Womens Health

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comment 1

Received: 2 August 2023
Commenter: Gayathri Delanerolle
Commenter's Conflict of Interests: Author

Comment: Change in one author; this was an administrative error

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