VACCINATON POLICIES IN SOLID ORGAN TRANSPLANT ADULT CANDIDATES AND RECIPIENTS

Viganò, M.; Beretta, M.; Lepore, M.; Abete, R.; Benatti, S.V.; Grassini, M.V.; Camagni, S.; Chiodini, G.; Vargiu, S.; Vittori, C.; Iachini, M.; Terzi, A.; Neri, F.; Pinelli, D.; Casotti, V.; Di Marco, F.; Ruggenenti, P.; Rizzi, M.; Colledan, M.; Fagiuoli, S. Vaccination Recommendations in Solid Organ Transplant Adult Candidates and Recipients. Vaccines 2023, 11, 1611. Viganò, M.; Beretta, M.; Lepore, M.; Abete, R.; Benatti, S.V.; Grassini, M.V.; Camagni, S.; Chiodini, G.; Vargiu, S.; Vittori, C.; Iachini, M.; Terzi, A.; Neri, F.; Pinelli, D.; Casotti, V.; Di Marco, F.; Ruggenenti, P.; Rizzi, M.; Colledan, M.; Fagiuoli, S. Vaccination Recommendations in Solid Organ Transplant Adult Candidates and Recipients. Vaccines 2023, 11, 1611.

Abstract

Prevention of infections is crucial in solid organ transplant (SOT) candidates and recipients. These pa-tients are exposed to an increased infectious risk due to previous organ insufficiency and to pharmaco-logic immunosuppression. Besides infectious-related morbidity and mortality, this vulnerable group of patients is also exposed to the risk of acute decompensation and organ rejection or failure in the pre- and post-transplant period respectively, since antimicrobial treatments are less effective than in the immunocompetent patients. Vaccination represents a major preventive measure against specific infec-tious risks in this population but as responses to vaccines are reduced, especially in the early post-transplant period or after treatment for rejection, an optimal vaccination status should be obtained prior to transplantation whenever possible. This review reports the currently available data on the indications and modalities of vaccination in SOT adult candidates and recipients.

Keywords

solid organ transplantation; vaccination; chronic diseases; liver; lungs; heart; kidney; infections; prevention.

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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