Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease

Andrea Costantino; Marco Michelon; Daniele Noviello; Fabio Salvatore Macaluso; Marina Aloi; Alessandro Armuzzi; Fabrizio Bossa; Ferdinando Ficari; Salvo Leone; Francesco Manguso; Giammarco Mocci; Ambrogio Orlando; Loris Pironi; Simona Radice; Fernando Rizzello; Alessandra Tongiorgi; Nicole Bonaccorso; Claudio Costantino; Maurizio Vecchi; Flavio Caprioli

doi:10.20944/preprints202307.1496.v1

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preprints.org > medicine and pharmacology > gastroenterology and hepatology > doi: 10.20944/preprints202307.1496.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease

Andrea Costantino

^* ,

Marco Michelon

Daniele Noviello

Fabio Salvatore Macaluso

Version 1 : Received: 20 July 2023 / Approved: 21 July 2023 / Online: 21 July 2023 (11:35:22 CEST)

A peer-reviewed article of this Preprint also exists.

Costantino, A.; Michelon, M.; Noviello, D.; Macaluso, F.S.; Leone, S.; Bonaccorso, N.; Costantino, C.; Vecchi, M.; Board, F.C. Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease. Vaccines 2023, 11, 1591. Costantino, A.; Michelon, M.; Noviello, D.; Macaluso, F.S.; Leone, S.; Bonaccorso, N.; Costantino, C.; Vecchi, M.; Board, F.C. Attitudes towards Vaccinations in a National Italian Cohort of Patients with Inflammatory Bowel Disease. Vaccines 2023, 11, 1591.

Abstract

Abstract: Background: The vaccination status of patients with inflammatory bowel disease (IBD) should be investigated before starting any treatment, and patients eventually vaccinated against vaccine preventable diseases (VPDs). Vaccination rates in patients with IBD are known to be suboptimal. The aim of this study was to investigate the vaccination coverage, attitude towards vaccinations and its possible determinants among a national cohort of IBD patients. Methods: An anonymous web-based questionnaire was sent by the Italian IBD patients’ association (AMICI) in February 2021. Previous vaccination status and patients’ attitude towards vaccinations were rec-orded. The factors influencing their attitudes were examined using crude and adjusted odds ratios (AdjORs) with 95% confidence intervals (CIs). Results: Among 4039 patients invited, 1252 patients (including 729 women, median age 47.7 [37–58]) completed the questionnaire, a response rate of 25.3%. Patients declared being vaccinated against: 74.1% tetanus, 67.7% flu (last season), 43.3% MMR, 37.1% HBV, 29.1% pneumococcus, 20% meningitis, 16% HAV, 15.3% VZV, 7.6% HPV. Two hundred and fifty-nine (20.7%) did not remember every previous vaccination. One thousand one hundred and twelve (88.8%) expressed a positive attitude towards vaccination, 91 (7.3%) were indifferent, 49 (3.9%) reported being opposed to vaccinations. The belief of possible return of VPDs with decline of vaccination coverage rates was the factor most strongly related to a positive at-titude towards vaccinations (AdjOR 5.67, 95% CI 3.45-9.30, p-value <0.001). Conclusions: A low vaccination rate against some VPDs was found among a national cohort of patients with IBD, despite a generally positive attitude towards vaccinations.

Keywords

inflammatory bowel disease; IBD; Crohn’s disease; Ulcerative colitis; vaccine, vaccination; vaccine hesitancy; VZV

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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