Version 1
: Received: 14 July 2023 / Approved: 17 July 2023 / Online: 17 July 2023 (11:10:13 CEST)
How to cite:
Perrotta, G.; Castellani, D. Updates about Wilms' Tumor: Pathogenesis, and New Possible Treatments of the Most Frequent Pediatric Urogenital Cancer. Preprints2023, 2023071086. https://doi.org/10.20944/preprints202307.1086.v1
Perrotta, G.; Castellani, D. Updates about Wilms' Tumor: Pathogenesis, and New Possible Treatments of the Most Frequent Pediatric Urogenital Cancer. Preprints 2023, 2023071086. https://doi.org/10.20944/preprints202307.1086.v1
Perrotta, G.; Castellani, D. Updates about Wilms' Tumor: Pathogenesis, and New Possible Treatments of the Most Frequent Pediatric Urogenital Cancer. Preprints2023, 2023071086. https://doi.org/10.20944/preprints202307.1086.v1
APA Style
Perrotta, G., & Castellani, D. (2023). Updates about Wilms' Tumor: Pathogenesis, and New Possible Treatments of the Most Frequent Pediatric Urogenital Cancer. Preprints. https://doi.org/10.20944/preprints202307.1086.v1
Chicago/Turabian Style
Perrotta, G. and Daniele Castellani. 2023 "Updates about Wilms' Tumor: Pathogenesis, and New Possible Treatments of the Most Frequent Pediatric Urogenital Cancer" Preprints. https://doi.org/10.20944/preprints202307.1086.v1
Abstract
Background: Wilms' tumor (or nephroblastoma) is a malignant and solid neoplasm that derives from the primitive renal bud. It represents the most frequent primary tumor of the urogenital tract in childhood, and treatment consists of surgery and chemo-radiotherapy. However, concerning the quality of life, the new therapeutic frontier is exploring other safer and potentially more effective options, such as minimally invasive surgery and biological drugs. Method: Literature (Pubmed) from January 2013 to March 2023 was reviewed. Results: One hundred five articles were included in the review. Conclusion: In addition to the therapeutic strategies already identified, such as classic surgery and pharmacological therapies, recent studies focus attention on the new frontiers of minimally invasive surgery, such as diagnostics using biomarkers and immunotherapy, which could represent a new therapeutic option and possibly less risky than in the past, contributing in fact to the current knowledge of the scientific panorama in terms of "tumor microenvironment" and systemic implications deriving from oncological disease.
Keywords
wilms; nephroblastoma; pediatric urogenital cancer
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
