Papaliagkas, V.; Lokantidou-Argyraki, C.; Patrikelis, P.; Zafeiridou, G.; Spilioti, M.; Afrantou, T.; Kosmidis, M.H.; Arnaoutoglou, M.; Kimiskidis, V.K. Cognitive Impairment in MRI-Negative Epilepsy: Relationship between Neurophysiological and Neuropsychological Measures. Diagnostics2023, 13, 2875.
Papaliagkas, V.; Lokantidou-Argyraki, C.; Patrikelis, P.; Zafeiridou, G.; Spilioti, M.; Afrantou, T.; Kosmidis, M.H.; Arnaoutoglou, M.; Kimiskidis, V.K. Cognitive Impairment in MRI-Negative Epilepsy: Relationship between Neurophysiological and Neuropsychological Measures. Diagnostics 2023, 13, 2875.
Papaliagkas, V.; Lokantidou-Argyraki, C.; Patrikelis, P.; Zafeiridou, G.; Spilioti, M.; Afrantou, T.; Kosmidis, M.H.; Arnaoutoglou, M.; Kimiskidis, V.K. Cognitive Impairment in MRI-Negative Epilepsy: Relationship between Neurophysiological and Neuropsychological Measures. Diagnostics2023, 13, 2875.
Papaliagkas, V.; Lokantidou-Argyraki, C.; Patrikelis, P.; Zafeiridou, G.; Spilioti, M.; Afrantou, T.; Kosmidis, M.H.; Arnaoutoglou, M.; Kimiskidis, V.K. Cognitive Impairment in MRI-Negative Epilepsy: Relationship between Neurophysiological and Neuropsychological Measures. Diagnostics 2023, 13, 2875.
Abstract
Background: Epileptic patients frequently encounter cognitive impairment. Functions that are mostly affected involve memory, attention and executive function; however this is mainly dependant on the location of the epileptic activity. The aim of the study is to assess cognitive functions in MRI-negative epilepsy patients by means of neurophysiological and neuropsychological measures. Methods: The patients were enrolled from the outpatient Epilepsy/Clinical Neurophysiology clinic over a time period of 6 months. The study sample comprised 20 MRI negative epilepsy patients [mean age ± standard deviation (SD), 30.3 ± 12.56 years; age range 16-60 years; average disease duration, 13.95 years) and 10 age-matched controls (mean age ± SD, 24.22 ± 15.39 years), that were also education-matched (p>0.05) Patients with epileptogenic lesions were excluded from the study. Informed consent was obtained from all subjects involved in the study. Auditory ERPs and the cognitive screening tool EpiTrack, were administered to all subjects. Results: Latencies of P300 and slow waves were prolonged in patients compared to controls (p<0.05). ASM load and the patients’ performance in the EpiTrack maze subtest were the most significant predictors of P300 latency. A decline in memory, attention, and speed of information processing has been observed in patients with cryptogenic epilepsy compared to age-matched controls, as reflected by P300 latency and EpiTrack scores.
Keywords
Event Related Potentials; Epilepsy; P300; Anti-Seizure Medication
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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