Version 1
: Received: 7 July 2023 / Approved: 11 July 2023 / Online: 12 July 2023 (05:42:56 CEST)
How to cite:
Shode, F.; Sabiu, S.; Aribisala, J.O.; Govender, K.K. An Updated Review (2015–2022) on the Phytochemistry and Pharmacological Importance of Lippia javanica (Burm. f.) Spreng.. Preprints2023, 2023070757. https://doi.org/10.20944/preprints202307.0757.v1
Shode, F.; Sabiu, S.; Aribisala, J.O.; Govender, K.K. An Updated Review (2015–2022) on the Phytochemistry and Pharmacological Importance of Lippia javanica (Burm. f.) Spreng.. Preprints 2023, 2023070757. https://doi.org/10.20944/preprints202307.0757.v1
Shode, F.; Sabiu, S.; Aribisala, J.O.; Govender, K.K. An Updated Review (2015–2022) on the Phytochemistry and Pharmacological Importance of Lippia javanica (Burm. f.) Spreng.. Preprints2023, 2023070757. https://doi.org/10.20944/preprints202307.0757.v1
APA Style
Shode, F., Sabiu, S., Aribisala, J.O., & Govender, K.K. (2023). An Updated Review (2015–2022) on the Phytochemistry and Pharmacological Importance of Lippia javanica (Burm. f.) Spreng.. Preprints. https://doi.org/10.20944/preprints202307.0757.v1
Chicago/Turabian Style
Shode, F., Jamiu Olaseni Aribisala and Krishna Kuben Govender. 2023 "An Updated Review (2015–2022) on the Phytochemistry and Pharmacological Importance of Lippia javanica (Burm. f.) Spreng." Preprints. https://doi.org/10.20944/preprints202307.0757.v1
Abstract
Lippia javanica (Burm. f.) is a medicinal plant with multiple native uses in the treatment of colds, influenza, pneumonia, coughs, dermatitis, tuberculosis, asthma, and bronchial diseases. However, it remains underutilized in drug development. In this review, existing studies on the pharmacological activities of L. javanica, more specifically the antitumor, antiviral, and antibacterial properties as well as recent metabolites identified from the plant were appraised. Background information on the plant's ecological distribution, ethnobotanical importance, toxicity, and cytotoxicity activity was also provided. The information in the review was gathered from major scientific databases (Google scholar, BioMed Central, Scopus, PubMed, Springer, Web of Science, and Science Direct) using journals, conference proceedings, dissertations, books, and/or chapters. The review compiled 66 new metabolites from the plant while establishing the anticancer, antiviral, antibacterial, and other important pharmacological activities of the organic (most especially methanol and acetone) and aqueous extracts of various parts of the plant attributed to several secondary metabolites present in the volatile oil of the plant, which includes carvone, ipsdienone, limonene, linalool, myrcene, ocimenone, caryophyllene, piperitenone, sabinene, p-cymene, sabinene, myrcene, ipsenone, and tagetenone. While some of the metabolites of L. javanica have been linked through pharmacological studies to the various traditional uses of the plant, some others remain unexplored, emphasizing how underutilized the plant is in drug research and development. It is envisaged that the reports from this review will help to further encourage future research and guide further investigations into the pharmaceutical and medicinal uses of L. javanica.
Keywords
Lippia javanica; Pharmacological; metabolites; ethnobotanical; drug discovery
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
