Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Chengqian Chen
ORCID logo ,
Peiru Wang
,
Linglin Zhang
,
Xiaojing Liu
,
Haiyan Zhang
,
Yajing Cao
,
Xiuli Wang
* ,
Qingyu Zeng
*
Version 1 : Received: 5 July 2023 / Approved: 5 July 2023 / Online: 6 July 2023 (09:02:30 CEST)

A peer-reviewed article of this Preprint also exists.

Chen, C.; Wang, P.; Zhang, L.; Liu, X.; Zhang, H.; Cao, Y.; Wang, X.; Zeng, Q. Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates. Biomedicines 2023, 11, 2153. Chen, C.; Wang, P.; Zhang, L.; Liu, X.; Zhang, H.; Cao, Y.; Wang, X.; Zeng, Q. Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates. Biomedicines 2023, 11, 2153.

Abstract

Rosacea is a chronic inflammatory skin disease characterized by recurrent erythema, flushing, telangiectasia, papules, pustules, and phymatous changes in the central area of the face. Patients with this condition often experience a significant negative impact on their quality of life, self-esteem, and overall well-being. Despite its prevalence, the pathogenesis of rosacea is not yet fully understood. Recent research advances are reshaping our understanding of the underlying mechanisms of rosacea, and treatment options based on the pathophysiological perspective hold promise to improve patient outcomes and reduce incidence. In this comprehensive review, we investigate the pathogenesis of rosacea in-depth, with a focus on emerging and novel mechanisms, and provide an up-to-date overview of therapeutic strategies that target the diverse pathogenic mechanisms of rosacea. Lastly, we discuss potential future research directions aimed at enhancing our understanding of the condition and developing effective treatments.

Keywords

Rosacea; inflammation; inflammatory skin disease; pathogenesis; therapeutic strategies; treatment options

Subject

Medicine and Pharmacology, Dermatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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