Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

MOFs-Based Biosensors for the Detection of Carcinoembryonic Antigen: A Concise Review

Version 1 : Received: 1 July 2023 / Approved: 3 July 2023 / Online: 4 July 2023 (02:25:36 CEST)

A peer-reviewed article of this Preprint also exists.

Ibrahim, M.R.; Greish, Y.E. MOF-Based Biosensors for the Detection of Carcinoembryonic Antigen: A Concise Review. Molecules 2023, 28, 5970. Ibrahim, M.R.; Greish, Y.E. MOF-Based Biosensors for the Detection of Carcinoembryonic Antigen: A Concise Review. Molecules 2023, 28, 5970.

Abstract

Cancer has been considered one of the most serious diseases in recent decades. Early diagnosis of cancer is a crucial step for an expedited treatment. Ideally, detection of cancer biomarkers, which are usually elevated because of cancer, is the most straightforward approach to detect cancer. Consequently, the accurate, effective, and prompt detection of these compounds is an insistent need for the medical diagnosis of the disease in order to start an early therapy plan for the patients. Among these biomarkers, Carcinoembryonic antigen (CEA) is considered one of the most important tumor markers for colorectal cancer, but it has been also used as a biomarker for other types of cancers, including breast, gastric, ovarian, pancreatic, and lung cancers. Typically, conventional CEA testing depends on immunoassay approaches, which are known to be complex, highly expensive, and time-consuming. In this context, many biosensors were designed for the aim of detecting cancer biomarkers. The main prerequisites of these biosensors are high sensitivity, fast response, and low cost. Many nanostructures have been involved in the design of biosensors. Metal organic frameworks (MOFs) were found to be one of the most potential and promising materials for biosensing. MOFs are highly porous and crystalline materials that consist of metal clusters surrounded by organic linkers, where the assembly of these components gives rise to the exquisite geometric 3D structures of MOFs. Moreover, the unique structure and geometry of MOFs allow for a better tailoring of their design to provide properties that are needed by different categories of biosensors. In the past few years, researchers have extensively considered MOFs for their fabrication of biosensors that can be used for the early detection of cancer biomarkers. In this regard, MOFs were used solely or were further decorated with other nanostructures to introduce more accurate signals and lower limits of detection. This review briefly classifies and describes MOFs-based biosensors trials that have been published recently for the aim of detecting CEA.

Keywords

Biosensors; Metal-organic frameworks; Carcinoembryonic antigen; Quantitative detection

Subject

Chemistry and Materials Science, Materials Science and Technology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.