Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of miRNAs in the Progression and Prognosis of Gliomas

Omar Bassam Tluli
ORCID logo ,
Mazyona Jumah Al-Maadhadi
,
Aisha Abdulla Al-Khulaifi
ORCID logo ,
Aishat Funmilayo Akomolafe
,
Shaikha Yousef Al-Kuwari
,
Roudha Saed Al-Khayarin
,
Cristina Maccalli
ORCID logo ,
Shona Pedersen
* ORCID logo
Version 1 : Received: 27 June 2023 / Approved: 28 June 2023 / Online: 28 June 2023 (11:06:15 CEST)

A peer-reviewed article of this Preprint also exists.

Tluli, O.; Al-Maadhadi, M.; Al-Khulaifi, A.A.; Akomolafe, A.F.; Al-Kuwari, S.Y.; Al-Khayarin, R.; Maccalli, C.; Pedersen, S. Exploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies. Cancers 2023, 15, 4213. Tluli, O.; Al-Maadhadi, M.; Al-Khulaifi, A.A.; Akomolafe, A.F.; Al-Kuwari, S.Y.; Al-Khayarin, R.; Maccalli, C.; Pedersen, S. Exploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies. Cancers 2023, 15, 4213.

Abstract

Gliomas, which arise from glial cells in the brain, remain a significant challenge due to their location and resistance to traditional treatments. Despite research efforts and advancements in healthcare, the incidence of gliomas has risen dramatically over the past two decades. The dysregulation of microRNAs (miRNAs) has prompted the creation of therapeutic agents that specially target them. However, it has been reported that they are involved in complex signaling pathways that contribute to the loss of expression of tumor suppressor genes and the upregulating of the expression of oncogenes. In addition, numerous miRNAs promote the development, progression, and recurrence of gliomas by targeting crucial proteins and enzymes involved in metabolic pathways such as glycolysis and oxidative phosphorylation. However, the complex interplay among these pathways and other obstacles hinder the ability to apply miRNA targeting in clinical practice. This underscores the importance of pinpointing miRNAs to be targeted for therapy and having a complete understanding of the diverse pathways they are involved in. Therefore, the aim of this review is to provide an overview on the role of miRNAs in the progression and prognosis of gliomas, emphasizing the different pathways involved and identifying potential therapeutic targets.

Keywords

microRNA; glioma; cancer stem cells.; prognosis; targeted therapy

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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