Huang, Z.; Dou, Y.; Su, J.; Li, T.; Song, S. Electrochemical Biosensing Methods for Detecting Epigenetic Modifications. Chemosensors2023, 11, 424.
Huang, Z.; Dou, Y.; Su, J.; Li, T.; Song, S. Electrochemical Biosensing Methods for Detecting Epigenetic Modifications. Chemosensors 2023, 11, 424.
Huang, Z.; Dou, Y.; Su, J.; Li, T.; Song, S. Electrochemical Biosensing Methods for Detecting Epigenetic Modifications. Chemosensors2023, 11, 424.
Huang, Z.; Dou, Y.; Su, J.; Li, T.; Song, S. Electrochemical Biosensing Methods for Detecting Epigenetic Modifications. Chemosensors 2023, 11, 424.
Abstract
Epigenetic modifications are closely related to diseases and physiological health, mainly including DNA methylation, RNA methylation, histone acetylation, and non-coding RNA. Recently, a large amount of research has been conducted on the detection of epigenetic modifications. Electrochemical biosensors, with their low cost, high sensitivity, high compatibility, and simple operation, have been widely used in the detection of epigenetic biomarkers. This review discusses the detection of epigenetic biomarkers using different electrochemical sensing methods. Here we discuss various aspects, including free labels, signal labeling, signal amplification, nano-based electrodes, and the combined use of other methods. By summarizing the existing electrochemical detection methods for epigenetic modifications, this review also proposes the future development trends and challenges for electrochemical biosensors in this field.
Keywords
epigenetic modifications; electrochemical biosensing; signal amplification; nanostructure modified electrodes
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
