Review
Version 1
Preserved in Portico This version is not peer-reviewed
Crimean–Congo Hemorrhagic Fever Virus: Progress in Vaccine Development
Version 1
: Received: 28 June 2023 / Approved: 28 June 2023 / Online: 28 June 2023 (08:32:49 CEST)
A peer-reviewed article of this Preprint also exists.
Ozdarendeli, A. Crimean–Congo Hemorrhagic Fever Virus: Progress in Vaccine Development. Diagnostics 2023, 13, 2708. Ozdarendeli, A. Crimean–Congo Hemorrhagic Fever Virus: Progress in Vaccine Development. Diagnostics 2023, 13, 2708.
Abstract
Crimean-Congo hemorrhagic fever virus (CCHFV), a member of the Nairoviridae family and Bunyavirales order, is transmitted to humans via tick bites or contact with the blood of infected animals. It can cause severe symptoms, including hemorrhagic fever, with a mortality rate between 5 to 30%. CCHFV is classified as a high-priority pathogen by the World Health Organization (WHO) due to its high fatality rate and the absence of effective medical countermeasures. CCHFV is endemic in several regions across the world, including Africa, Europe, the Middle East, and Asia, and has the potential for global spread. The emergence of the disease in new areas, as well as the presence of the tick vector in countries without reported cases, emphasizes the need for preventive measures should be taken. In the past, the lack of a suitable animal model susceptible to CCHFV infection has been a major obstacle in the development of vaccines and treatments. However, recent advances in biotechnology and the availability of suitable animal models have significantly expedited the development of vaccines against CCHF. These advancements have not only contributed to an enhanced understanding of the pathogenesis of CCHF but have also facilitated the evaluation of potential vaccine candidates. This review outlines of the immune response to CCHFV and animal models utilized for the study of CCHFV and highlights the progress made in CCHFV vaccine studies. Despite remarkable advancements in vaccine development for CCHFV, it remains crucial to prioritize continued research, collaboration, and investment in this field.
Keywords
Crimean–Congo hemorrhagic fever virus; hemorrhagic fever; immune response, animal models, vaccine development.
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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