PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Relationship Between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation-Antioxidant Defense System in Gastric Cancer Associated with Helicobacter Pylori Infection
Version 1
: Received: 23 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (12:54:01 CEST)
How to cite:
Smirnova, O.; Sinyakov, A.A.; Kasparov, E.V. Relationship Between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation-Antioxidant Defense System in Gastric Cancer Associated with Helicobacter Pylori Infection. Preprints2023, 2023061685. https://doi.org/10.20944/preprints202306.1685.v1
Smirnova, O.; Sinyakov, A.A.; Kasparov, E.V. Relationship Between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation-Antioxidant Defense System in Gastric Cancer Associated with Helicobacter Pylori Infection. Preprints 2023, 2023061685. https://doi.org/10.20944/preprints202306.1685.v1
Smirnova, O.; Sinyakov, A.A.; Kasparov, E.V. Relationship Between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation-Antioxidant Defense System in Gastric Cancer Associated with Helicobacter Pylori Infection. Preprints2023, 2023061685. https://doi.org/10.20944/preprints202306.1685.v1
APA Style
Smirnova, O., Sinyakov, A.A., & Kasparov, E.V. (2023). Relationship Between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation-Antioxidant Defense System in Gastric Cancer Associated with Helicobacter Pylori Infection. Preprints. https://doi.org/10.20944/preprints202306.1685.v1
Chicago/Turabian Style
Smirnova, O., Alexander Alexandrovich Sinyakov and Eduard Vilyamovich Kasparov. 2023 "Relationship Between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation-Antioxidant Defense System in Gastric Cancer Associated with Helicobacter Pylori Infection" Preprints. https://doi.org/10.20944/preprints202306.1685.v1
Abstract
Aim. To study the processes of lipid peroxidation and the activity of antioxidant defense enzymes depending on the chemiluminescent activity of neutrophilic granulocytes in patients with gastric cancer associated with H. pylori infection, depending on the stage.
Materials and methods. 39 patients with stage I-II gastric cancer and 30 patients with stage III-IV gastric cancer were examined. The study of the chemiluminescent activity of neutrophilic granulocytes was carried out, the parameters of the lipid peroxidation system and antioxidant protection in plasma were determined using the spectrophotometric method. Statistical data processing was performed using the Statistica 7.0 software package (StatSoft, USA).
Results. In patients with gastric cancer associated with H. pylori infection, regardless of stage, the proportion of neutrophilic granulocytes with normal activity does not exceed 1/3 of the total number of patients, the remaining 2/3 of patients have an altered chemiluminescent activity of neutrophilic granulocytes: in patients with gastric cancer by I -II stage of the disease, the majority revealed a reduced function of neutrophilic granulocytes, and in patients with gastric cancer stage III-IV of the disease, the majority showed increased chemiluminescent activity of neutrophilic granulocytes. In all patients with gastric cancer associated with H. pylori infection, regardless of the stage of the disease, an increase in lipid peroxidation processes with activation of antioxidant defense enzymes was detected.
Conclusion. In all patients with gastric cancer associated with H. pylori infection, regardless of the stage of the disease, an increase in lipid peroxidation processes with activation of antioxidant defense enzymes was detected. At the same time, there are no statistically significant differences between the indicators of the system lipid peroxidation - antioxidant protection depending on the stage of gastric cancer and the chemiluminescent activity of neutrophilic granulocytes, which probably indicates that all reactive oxygen species produced by neutrophilic granulocytes in the respiratory burst are consumed locally, minimally affecting the development of oxidative stress in the blood plasma.
Keywords
Gastric cancer; H. pylori; activity of neutrophilic granulocytes; oxidative stress.
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
