Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review

Mohamed Radwan; Howaida I. Abd-Alla; Hatem Elmezayen; Mohammed A.S. Abourehab; Mohamed E. El‐Beeh; Hiroshi Tateishi; Masami Otsuka; Mikako Fujita

doi:10.20944/preprints202306.1671.v1

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preprints.org > chemistry and materials science > medicinal chemistry > doi: 10.20944/preprints202306.1671.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review

Mohamed Radwan

^* ,

Howaida I. Abd-Alla

Hatem Elmezayen

Mohammed A.S. Abourehab

Version 1 : Received: 22 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (11:55:35 CEST)
Version 2 : Received: 5 July 2023 / Approved: 10 July 2023 / Online: 10 July 2023 (14:23:12 CEST)

How to cite: Radwan, M.; Abd-Alla, H. I.; Elmezayen, H.; Abourehab, M. A.; El‐Beeh, M. E.; Tateishi, H.; Otsuka, M.; Fujita, M. Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints 2023, 2023061671. https://doi.org/10.20944/preprints202306.1671.v1 Radwan, M.; Abd-Alla, H. I.; Elmezayen, H.; Abourehab, M. A.; El‐Beeh, M. E.; Tateishi, H.; Otsuka, M.; Fujita, M. Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints 2023, 2023061671. https://doi.org/10.20944/preprints202306.1671.v1

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MDPI and ACS Style

Radwan, M.; Abd-Alla, H. I.; Elmezayen, H.; Abourehab, M. A.; El‐Beeh, M. E.; Tateishi, H.; Otsuka, M.; Fujita, M. Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints 2023, 2023061671. https://doi.org/10.20944/preprints202306.1671.v1

APA Style

Radwan, M., Abd-Alla, H. I., Elmezayen, H., Abourehab, M. A., El‐Beeh, M. E., Tateishi, H., Otsuka, M., & Fujita, M. (2023). Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review. Preprints. https://doi.org/10.20944/preprints202306.1671.v1

Chicago/Turabian Style

Radwan, M., Masami Otsuka and Mikako Fujita. 2023 "Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review" Preprints. https://doi.org/10.20944/preprints202306.1671.v1

Abstract

Abstract: In the last decade, gypsogenin has widely grabbed the attention of medicinal chemists by virtue of its prominent anti-cancer potential. Despite its late identification, gypsogenin proved itself as a new an-ti-proliferative player battling for a front position among other classic pentacyclic triterpenes such as oleanolic acid, glycyrrhetinic acid, ursolic acid, betulinic acid, and celastrol. Herein, we present insights into the anti-cancer activity of gypsogenin and its semisynthetic derivatives and go further by introducing our perspective to judiciously guide the prospect rational design. The present article opens a new venue for better exploitation of gypsogenin chemical entity as a lead compound in cancer chemotherapy. To the best of our knowledge, this is the first review article exploring the anti-cancer activity of gypsogenin derivatives.

Keywords

pentacyclic triterpenes; gypsogenin; anti-cancer

Subject

Chemistry and Materials Science, Medicinal Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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