Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Profile of SARS-CoV-2 Infection: Mechanisms of the Cellular Immune Response and Immunogenetic Markers in Patients from Brazil

Vanessa Pacheco
,
Rosane Cuber Guimarães
,
Danielly Corrêa-Moreira
ORCID logo ,
Carlos Eduardo Magalhães
,
Douglas Figueiredo
,
Patricia Guttmann
,
Gisela Freitas Trindade
,
Juliana Fernandes Amorim Da Silva
,
Ana Paula Dinis Ano Bom
,
Maria de Lourdes Maia
,
Manoel Marques Evangelista Oliveira
* ORCID logo
Version 1 : Received: 16 June 2023 / Approved: 19 June 2023 / Online: 19 June 2023 (10:57:08 CEST)

A peer-reviewed article of this Preprint also exists.

Pacheco, V.; Cuber Guimarães, R.; Corrêa-Moreira, D.; Magalhães, C.E.; Figueiredo, D.; Guttmann, P.; Trindade, G.F.; da Silva, J.F.A.; Ano Bom, A.P.D.; de Lourdes Maia, M.; Melgaço, J.G.; da Costa Barros, T.A.; da Silva, A.M.V.; Group, C.; Oliveira, M.M.E. Clinical Profile of SARS-CoV-2 Infection: Mechanisms of the Cellular Immune Response and Immunogenetic Markers in Patients from Brazil. Viruses 2023, 15, 1609. Pacheco, V.; Cuber Guimarães, R.; Corrêa-Moreira, D.; Magalhães, C.E.; Figueiredo, D.; Guttmann, P.; Trindade, G.F.; da Silva, J.F.A.; Ano Bom, A.P.D.; de Lourdes Maia, M.; Melgaço, J.G.; da Costa Barros, T.A.; da Silva, A.M.V.; Group, C.; Oliveira, M.M.E. Clinical Profile of SARS-CoV-2 Infection: Mechanisms of the Cellular Immune Response and Immunogenetic Markers in Patients from Brazil. Viruses 2023, 15, 1609.

Abstract

Objectives: The aim of this study is to evaluate some mechanisms of the immune response of people infected with SARS-CoV-2 in both acute infection and early and late convalescence phases. Methods: This is a cohort study of 70 cases of COVID-19, confirmed by RT-PCR, followed up to 60 days. Plasma Samples and clinical data were. Viral load, blood count, indicators inflammation were the parameters evaluated. Cellular immune response was evaluated by flow cytometry and Luminex immunoassays. Results: In the severe group, hypertension was the only reported comorbidity. Non severe patients have activated memory naive CD4+ T cells. Critically ill patients have central memory CD4+ T cell activation. Severe COVIS-19 patients have both central memory TCD8+ T cells and activated effector TCD8+ cells. Non-severe COVID-19 cases showed an increase in IL1β, IL-6, IL-10 and TNF and severely ill patients had higher levels of the cytokines IL-6, IL-10 and CXCL8.Conclusion: The present work showed that different cellular responses are observed according to the COVID-19 severity in patients from Brazil an epicenter the pandemic in South America. Also, we notice that some cytokines can be used as predictive markers for the disease outcome, possibility implementation of strategies effective by health managers.

Keywords

Sars-Cov-2; COVID-19; Immune response; Cytokine storm; acute infection

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.