Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exploring Therapeutic Applications of Autophagy in Spike Protein-Related Pathology

Version 1 : Received: 17 June 2023 / Approved: 19 June 2023 / Online: 19 June 2023 (07:39:57 CEST)

A peer-reviewed article of this Preprint also exists.

Halma, M. T., Marik, P. E., & Saleeby, Y. M. (2023). Exploring Autophagy in Treating Spike Protein-related Pathology. Halma, M. T., Marik, P. E., & Saleeby, Y. M. (2023). Exploring Autophagy in Treating Spike Protein-related Pathology.


Fasting, a practice with historical roots in various cultures, has recently garnered significant interest in the field of medicine. In this article, we delve into the mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore the therapeutic potential of fasting on spike protein-related pathology. Additionally, we discuss factors that affect fasting, such as duration, type (dry vs. water), and the role of specific compounds like spermidine, resveratrol, rapamycin, and metformin. Furthermore, we analyse the interactions between fasting and other practices such as exercise, and highlight important considerations regarding participant characteristics, including pregnancy, breastfeeding, medication interactions, and metabolic disorders. In conclusion, fasting, coupled with an understanding of its nuances, holds promise as a therapeutic intervention with broad implications for human health.


Fasting; autophagy; long-COVID; post-vaccination syndrome; spike protein; mitochondria; mitophagy


Medicine and Pharmacology, Endocrinology and Metabolism

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