Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Investigation Detection of Antibody+Antigen Complexes by SOI-FET Biosensor

Vladimir Generalov
* ORCID logo ,
Anastasia Cheremiskina
ORCID logo ,
Aleksandr Glukhov
,
Victoria Grabezhova
,
Margarita Kruchinina
ORCID logo ,
Aleksandr Safatov
ORCID logo
Version 1 : Received: 16 June 2023 / Approved: 16 June 2023 / Online: 16 June 2023 (11:49:20 CEST)

A peer-reviewed article of this Preprint also exists.

Generalov, V.; Cheremiskina, A.; Glukhov, A.; Grabezhova, V.; Kruchinina, M.; Safatov, A. Investigation of Limitations in the Detection of Antibody + Antigen Complexes Using the Silicon-on-Insulator Field-Effect Transistor Biosensor. Sensors 2023, 23, 7490. Generalov, V.; Cheremiskina, A.; Glukhov, A.; Grabezhova, V.; Kruchinina, M.; Safatov, A. Investigation of Limitations in the Detection of Antibody + Antigen Complexes Using the Silicon-on-Insulator Field-Effect Transistor Biosensor. Sensors 2023, 23, 7490.

Abstract

Detection of virus in sample is an actual problem in biotechnology, virology, medicine using biosensor. History of problem dates back to middle of last century and is associated with development of an ion-sensitive solid-state device for neurophysiological measurements. Aim of work is theoretical investigation process of detection antibody+antigen (AB+AG) complexes using SOI-FET biosensor. On example of crystal with ten biosensors, estimates of probability detection AB+AG complexes influenza virus are made. In detection process, following four results are possible: – target complex is present in test sample, and it was correctly detected; – target complex is present in sample, but it was not detected; – target complex is absent in sample, but background particles are mistakenly detected as target complex; – target complex is absent in sample, background particles present in sample and are correctly detected as noise.

Keywords

biosensor; SOI-FET; transistor; detection; virus; particles; probability; plausibility

Subject

Biology and Life Sciences, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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