Version 1
: Received: 13 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (10:02:30 CEST)
How to cite:
Zhang, M.; Ge, M.; Li, Q.; Li, H.; Jiao, L.; Wu, W. A Review on the Research Progress of Mechanism of Panax ginseng C. A. meyer in the Treatment of Alzheimer’s Disease. Preprints2023, 2023060919. https://doi.org/10.20944/preprints202306.0919.v1
Zhang, M.; Ge, M.; Li, Q.; Li, H.; Jiao, L.; Wu, W. A Review on the Research Progress of Mechanism of Panax ginseng C. A. meyer in the Treatment of Alzheimer’s Disease. Preprints 2023, 2023060919. https://doi.org/10.20944/preprints202306.0919.v1
Zhang, M.; Ge, M.; Li, Q.; Li, H.; Jiao, L.; Wu, W. A Review on the Research Progress of Mechanism of Panax ginseng C. A. meyer in the Treatment of Alzheimer’s Disease. Preprints2023, 2023060919. https://doi.org/10.20944/preprints202306.0919.v1
APA Style
Zhang, M., Ge, M., Li, Q., Li, H., Jiao, L., & Wu, W. (2023). A Review on the Research Progress of Mechanism of <em>Panax ginseng C. A. meyer </em>in the Treatment of Alzheimer’s Disease. Preprints. https://doi.org/10.20944/preprints202306.0919.v1
Chicago/Turabian Style
Zhang, M., Lili Jiao and Wei Wu. 2023 "A Review on the Research Progress of Mechanism of <em>Panax ginseng C. A. meyer </em>in the Treatment of Alzheimer’s Disease" Preprints. https://doi.org/10.20944/preprints202306.0919.v1
Abstract
Panax ginseng C. A. Meyer (P. ginseng), has been widely used in traditional Chinese medicine (TCM). It contains a number of chemical components and possesses a variety of pharmacological activities. Alzheimer's disease (AD) is neurodegenerative disease that creates a huge burden on the lives and health of individuals. In recent years, studies have indicated that the chemical components of P. ginseng, especially ginsenosides, play a pronounced positive role in the prevention and treatment of neurological diseases. This review aimed to summarize currently studies on chemical components and the mechanisms action in AD intervention treatment of P. ginseng, especially ginsenosides. In this review, the components of P. ginseng and their respective active effects were first introduced. Then the key molecular mechanisms and signaling pathways of P. ginseng were introduced, and its different active ingredients in the prevention and treatment of Alzheimer's disease-related pathogenesis were also summarized from the pathogenesis of AD Aβ generation and aggregation, hyperphosphorylation of tau protein，oxidant stress，neuroinflammation，mitochondrial damage，disorder of neurotransmitter and gut microbiota. Signaling pathway networks related to the action of ginseng active ingredients was constructed, which could serve as a therapeutic target for Alzheimer's disease. In addition to a detailed report on P. ginseng in improving Alzheimer's disease-related pathogenesis, the application of the current technology, spatial metabonomics in AD therapeutics and diagnostics were later discussed. Spatial metabonomics could be applied to investigate the multi-target intervention of P. ginseng on Alzheimer's disease. Research perspectives for the study of P. ginseng in the treatment of Alzheimer's disease were provided for further studies.
Keywords
P. ginseng; chemical component; ginsenoside; Alzheimer's disease; signaling pathways; spatial metabolomics
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
