Version 1
: Received: 8 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (03:27:48 CEST)
Version 2
: Received: 28 November 2023 / Approved: 29 November 2023 / Online: 29 November 2023 (11:06:02 CET)
How to cite:
Zaretsky, D.V.; Zaretskaia, M.V. Amyloid Degradation Toxicity Hypothesis: Integrative Theory of Alzheimer’s Disease. Preprints2023, 2023060807. https://doi.org/10.20944/preprints202306.0807.v1
Zaretsky, D.V.; Zaretskaia, M.V. Amyloid Degradation Toxicity Hypothesis: Integrative Theory of Alzheimer’s Disease. Preprints 2023, 2023060807. https://doi.org/10.20944/preprints202306.0807.v1
Zaretsky, D.V.; Zaretskaia, M.V. Amyloid Degradation Toxicity Hypothesis: Integrative Theory of Alzheimer’s Disease. Preprints2023, 2023060807. https://doi.org/10.20944/preprints202306.0807.v1
APA Style
Zaretsky, D.V., & Zaretskaia, M.V. (2023). Amyloid Degradation Toxicity Hypothesis: Integrative Theory of Alzheimer’s Disease. Preprints. https://doi.org/10.20944/preprints202306.0807.v1
Chicago/Turabian Style
Zaretsky, D.V. and Maria V. Zaretskaia. 2023 "Amyloid Degradation Toxicity Hypothesis: Integrative Theory of Alzheimer’s Disease" Preprints. https://doi.org/10.20944/preprints202306.0807.v1
Abstract
Amyloid degradation toxicity hypothesis is the integrative theory of Alzheimer’s disease (AD). It successfully interprets phenomena and paradoxes associated with AD pathobiology. The hypothesis explains the limitations of currently used biomarkers of AD and proposes etiology-related parameters. These parameters could be measured in humans and become novel diagnostic and prognostic clinical tools. Based on the proposed framework, we foresee the development of effective medications to treat, stall the progression of, or prevent the development of the disease. The promise is supported by published preclinical data. This manuscript summarizes the amyloid degradation toxicity hypothesis of Alzheimer’s disease at different levels of organization.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
