PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Transmission of Rubella and Risk of Congenital Rubella Syndrome (Crs) in Pregnant Women during Prenatal Consultation at the Sino – Gabonese Friendship Hospital in Franceville
Version 1
: Received: 29 May 2023 / Approved: 7 June 2023 / Online: 7 June 2023 (03:52:24 CEST)
How to cite:
Adelaïde, N.; Sima, C.O.; Ndong Mba, T.; Mba, K.P.B.; Nzamba, U.; Kenguele, H.M.; Pambo Pambo, A.B.; Cyrille Bisseye, C.; Mickala, P. Transmission of Rubella and Risk of Congenital Rubella Syndrome (Crs) in Pregnant Women during Prenatal Consultation at the Sino – Gabonese Friendship Hospital in Franceville. Preprints2023, 2023060481. https://doi.org/10.20944/preprints202306.0481.v1
Adelaïde, N.; Sima, C.O.; Ndong Mba, T.; Mba, K.P.B.; Nzamba, U.; Kenguele, H.M.; Pambo Pambo, A.B.; Cyrille Bisseye, C.; Mickala, P. Transmission of Rubella and Risk of Congenital Rubella Syndrome (Crs) in Pregnant Women during Prenatal Consultation at the Sino – Gabonese Friendship Hospital in Franceville. Preprints 2023, 2023060481. https://doi.org/10.20944/preprints202306.0481.v1
Adelaïde, N.; Sima, C.O.; Ndong Mba, T.; Mba, K.P.B.; Nzamba, U.; Kenguele, H.M.; Pambo Pambo, A.B.; Cyrille Bisseye, C.; Mickala, P. Transmission of Rubella and Risk of Congenital Rubella Syndrome (Crs) in Pregnant Women during Prenatal Consultation at the Sino – Gabonese Friendship Hospital in Franceville. Preprints2023, 2023060481. https://doi.org/10.20944/preprints202306.0481.v1
APA Style
Adelaïde, N., Sima, C.O., Ndong Mba, T., Mba, K.P.B., Nzamba, U., Kenguele, H.M., Pambo Pambo, A.B., Cyrille Bisseye, C., & Mickala, P. (2023). Transmission of Rubella and Risk of Congenital Rubella Syndrome (Crs) in Pregnant Women during Prenatal Consultation at the Sino – Gabonese Friendship Hospital in Franceville. Preprints. https://doi.org/10.20944/preprints202306.0481.v1
Chicago/Turabian Style
Adelaïde, N., Cyrille Cyrille Bisseye and Patrick Mickala. 2023 "Transmission of Rubella and Risk of Congenital Rubella Syndrome (Crs) in Pregnant Women during Prenatal Consultation at the Sino – Gabonese Friendship Hospital in Franceville" Preprints. https://doi.org/10.20944/preprints202306.0481.v1
Abstract
Objectives: Pregnant women represent a population category at high risk of severe rubella infection, capable of adversely affecting their fetus. This study was conducted to determine the seroprevalence of anti-rubella antibodies in pregnant women seen in prenatal consultations at the Sino-Gabonese Friendship Hospital in Franceville
Patients and Methods: A prospective, cross-sectional study was conducted at the Sino-Gabonese Friendship Hospital in Franceville, from April 3 to July 27, 2023. Using a structured and pre-established questionnaire, sociodemographic and obstetrical characteristics were obtained... Three milliliters of blood were collected from participants to measure rubella-specific IgG antibody levels using the OnSite Rapid Test Rubella IgG/IgM COMBO lateral flow immunochromatographic assay. Results were considered significant at p≤0.05.
Results: The study included 107 pregnant women seen in prenatal consultations. With a mean age of 27.9±7.1 years, anti-Rubella IgG antibodies were found in 87 pregnant women, indicating an overall seroprevalence of 81.30% (95% CI: [0.72 - 0.87). Of these, 6.9% (n = 6) of the women were serum anti-Rubivirus IgM carriers. In univariate analysis, it was indicated that pregnant women in the study aged between 21-30 years (OR =0.33; 95% CI: [0.12-0.9] p=0.0027), student (OR =6.35; 95% CI: [1.39-29.09] p=0.001), or without professional status (OR =0.05; 95% CI: [0.01- 0.27] p<0.001), high school education (OR =8.24; 95% CI: [2.83-23.96] p<0.001), single (OR =0.3; 95% CI: [0.11-0.85] p=0.0021) or cohabiting OR =3.91; 95% CI: [1.21-12.64] p=0.0017) Residing in an urban area (OR =49; 95% CI: [1.43-16.75] p=0.006), in the first trimester of their pregnancy (OR = 0.29; 95% CI: [0.09-0.94] p= 0.033), with a history of spontaneous abortion (OR = 0.09; 95% CI: [1.04; 11.30] p= 0. 037), and unvaccinated (OR = 0.13; 95% CI: [0.05; 0.13] p<0.000), had an elevated risk of Rubella, After adjusting for risk factors by logistic regression, residence in a rural area (ORA = 139.87 95% CI : [1.74 -11236.216] p=0.027),and no vaccination (ORA = 43.3 95% CI: [1.13 -1662.7] p= 0.043), were identified as the only significant risk factors for Rubella for the present study population
Conclusion: The high rate of susceptibility to rubella among pregnant women in the present study indicates that any short-term vaccination strategy aimed at reducing the number of susceptible women of childbearing age is imperative
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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