PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Prospective Cohort Study of Protective Effect of Neonatal Tuberculosis and Hepatitis B Vaccination against Development of Atopic Dermatitis: Interim Results of 18-Month Follow-Up
Version 1
: Received: 2 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (07:57:17 CEST)
How to cite:
Fedoseenko, M.; Petrova, V.; Namazova-Baranova, L. Prospective Cohort Study of Protective Effect of Neonatal Tuberculosis and Hepatitis B Vaccination against Development of Atopic Dermatitis: Interim Results of 18-Month Follow-Up. Preprints2023, 2023060252. https://doi.org/10.20944/preprints202306.0252.v1
Fedoseenko, M.; Petrova, V.; Namazova-Baranova, L. Prospective Cohort Study of Protective Effect of Neonatal Tuberculosis and Hepatitis B Vaccination against Development of Atopic Dermatitis: Interim Results of 18-Month Follow-Up. Preprints 2023, 2023060252. https://doi.org/10.20944/preprints202306.0252.v1
Fedoseenko, M.; Petrova, V.; Namazova-Baranova, L. Prospective Cohort Study of Protective Effect of Neonatal Tuberculosis and Hepatitis B Vaccination against Development of Atopic Dermatitis: Interim Results of 18-Month Follow-Up. Preprints2023, 2023060252. https://doi.org/10.20944/preprints202306.0252.v1
APA Style
Fedoseenko, M., Petrova, V., & Namazova-Baranova, L. (2023). Prospective Cohort Study of Protective Effect of Neonatal Tuberculosis and Hepatitis B Vaccination against Development of Atopic Dermatitis: Interim Results of 18-Month Follow-Up. Preprints. https://doi.org/10.20944/preprints202306.0252.v1
Chicago/Turabian Style
Fedoseenko, M., Veronika Petrova and Leyla Namazova-Baranova. 2023 "Prospective Cohort Study of Protective Effect of Neonatal Tuberculosis and Hepatitis B Vaccination against Development of Atopic Dermatitis: Interim Results of 18-Month Follow-Up" Preprints. https://doi.org/10.20944/preprints202306.0252.v1
Abstract
Previous studies have shown that immunization within the first hours/days after birth promotes the shift from the intrauterine Th2 immune response toward the Th1 immunity resulting in lower risk of developing allergic diseases. We are currently conducting a prospective cohort study among 307 participants divided into groups based on their TB and hepatitis B vaccination status (vaccinated at birth, within the first 12 months of life or unvaccinated) and also based on whether the participants had factors contributing to the development of allergic diseases. In each group we assessed the fact of primary diagnosis of atopic dermatitis at 12 and 18 months of age. It was demonstrated that atopic dermatitis (AD) was diagnosed from birth to 12 months of age much less frequently in those infants who had received the tuberculosis (TB) vaccine from day 3 to day 7 and hepatitis B vaccine within the first 24 hours of birth, including newborns with a high risk of developing allergic diseases. The probability of onset of AD at 12 and 18 months was also lower in timely vaccinated children, even though a burdened allergic anamnesis starts playing a more central role in development of AD at this age. Our findings testify to the fact that timely BCG-M and hepatitis B vaccination can produce a protective effect against the onset of AD, yet this effect diminishes with aging.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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