Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

Version 1 : Received: 1 June 2023 / Approved: 1 June 2023 / Online: 1 June 2023 (13:57:28 CEST)

A peer-reviewed article of this Preprint also exists.

Akiyama, Y.; Katsuki, S.; Matoba, T.; Nakano, Y.; Takase, S.; Nakashiro, S.; Yamamoto, M.; Mukai, Y.; Inoue, S.; Oi, K.; Higo, T.; Takemoto, M.; Suematsu, N.; Eshima, K.; Miyata, K.; Usui, M.; Sadamatsu, K.; Kadokami, T.; Hironaga, K.; Ichi, I.; Todaka, K.; Kishimoto, J.; Tsutsui, H. Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis. Nutrients 2023, 15, 2997. Akiyama, Y.; Katsuki, S.; Matoba, T.; Nakano, Y.; Takase, S.; Nakashiro, S.; Yamamoto, M.; Mukai, Y.; Inoue, S.; Oi, K.; Higo, T.; Takemoto, M.; Suematsu, N.; Eshima, K.; Miyata, K.; Usui, M.; Sadamatsu, K.; Kadokami, T.; Hironaga, K.; Ichi, I.; Todaka, K.; Kishimoto, J.; Tsutsui, H. Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis. Nutrients 2023, 15, 2997.

Abstract

Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n=207) who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally. We measured lipid profiles including serum oxysterols. As for the serum biomarkers of cholesterol synthesis and absorption, oxysterol levels were positively correlated with campesterol and lathosterol. Covariance structure analysis revealed that dyslipidemia and statin usage had a positive correlation with “cholesterol absorption”. Statin usage also had a positive correlation with “cholesterol synthesis” Several oxysterols associated with cholesterol absorption and/or synthesis. In conclusion, we elucidated the potential clinical factors that may affect cholesterol metabolism, and the associations between various oxysterols with cholesterol absorption and/or synthesis in patients with coronary artery disease.

Keywords

oxysterol; cardiovascular disease; cholesterol metabolism

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.