Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Maternal and Infant Histo-Blood Group Antigens (Hbga) Profiles and It’s Influence on Oral Rotavirus Vaccine (Rotarix®) Immunogenicity Among Infants in Zambia

Adriace Chauwa
* ,
Natasha Makabilo Laban
ORCID logo ,
Samuel Bosomprah
,
Bernard Phiri
,
Mwelwa Chibuye
,
Obvious Nchimunya Chilyabanyama
,
Sody Munsaka
,
Michelo Simuyandi
ORCID logo ,
Innocent Mwape
,
Cynthia Mubanga
,
Masuzyo Chirwa
,
Caroline Chisenga
,
Roma Chilengi
Version 1 : Received: 30 May 2023 / Approved: 31 May 2023 / Online: 31 May 2023 (08:43:17 CEST)

A peer-reviewed article of this Preprint also exists.

Chauwa, A.; Bosomprah, S.; Laban, N.M.; Phiri, B.; Chibuye, M.; Chilyabanyama, O.N.; Munsaka, S.; Simuyandi, M.; Mwape, I.; Mubanga, C.; Chobe, M.C.; Chisenga, C.; Chilengi, R. Maternal and Infant Histo-Blood Group Antigen Profiles and Their Influence on Oral Rotavirus Vaccine Immunogenicity among Infants in Zambia. Vaccines 2023, 11, 1303. Chauwa, A.; Bosomprah, S.; Laban, N.M.; Phiri, B.; Chibuye, M.; Chilyabanyama, O.N.; Munsaka, S.; Simuyandi, M.; Mwape, I.; Mubanga, C.; Chobe, M.C.; Chisenga, C.; Chilengi, R. Maternal and Infant Histo-Blood Group Antigen Profiles and Their Influence on Oral Rotavirus Vaccine Immunogenicity among Infants in Zambia. Vaccines 2023, 11, 1303.

Abstract

Live-attenuated, oral rotavirus vaccines have significantly reduced rotavirus-associated diarrhoea morbidity and infant mortality. However, vaccine immunogenicity is diminished in low-income countries. We investigated whether maternal and infant intrinsic susceptibility to rotavirus infection via histo-blood group antigen (HBGA) profiles influenced rotavirus (ROTARIX®) vaccine-induced responses in Zambia. We studied 135 mother-infant pairs under a rotavirus vaccine clinical trial aged 6 to 12 weeks at pre-vaccination up to 12 months old. We determined maternal and infant ABO/H, Lewis, and secretor HBGA phenotypes, and infant FUT2 HBGA genotypes. Vaccine immunogenicity was measured as anti-rotavirus IgA antibody titres. Overall, 34 (31.3%) of children were seroconverted at 14 weeks, and no statistically significant difference in seroconversion was observed across the various HBGA profiles in early infant life. We also observed a statistically significant difference in rotavirus-IgA titres across infant HBGA profiles at 12 months though no statistically significant difference was observed between study arms. There was no association between maternal HBGA profiles and infant vaccine immunogenicity. Overall, infant HBGA was associated with RV-Vaccine immunogenicity at 12 months as opposed to early infant life. Further investigation into the low efficacy of ROTARIX® and appropriate intervention is key to unlocking full vaccine benefits for U5 children.

Keywords

Rotavirus; vaccines; histo-blood groups; immunogenicity; Zambia

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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