Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Overview of Catalytic Carbonylative Double Cyclization Reactions

Version 1 : Received: 30 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (14:10:04 CEST)

A peer-reviewed article of this Preprint also exists.

Gabriele, B.; Mancuso, R.; Della Ca’, N.; Veltri, L.; Ziccarelli, I. An Overview of Catalytic Carbonylative Double Cyclization Reactions. Catalysts 2023, 13, 1025. Gabriele, B.; Mancuso, R.; Della Ca’, N.; Veltri, L.; Ziccarelli, I. An Overview of Catalytic Carbonylative Double Cyclization Reactions. Catalysts 2023, 13, 1025.

Abstract

This short review is aimed at giving an overview of catalytic carbonylative double cyclization reactions, which are processes in which suitable organic substrates and carbon monoxide are sequentially activated by a promoting catalyst to afford the formation of two new cycles with concomitant incorporation of carbon monoxide as a carbonyl function into the final product. Paradigmatic examples of this powerful synthetic methodology, which allows the one-step synthesis of complex molecular architectures from simple building blocks using the simplest and readily available C-1 unit (CO) are illustrated and discussed. The review is divided into five sections: 1) Introduction; 2) Functionalized Olefinic Substrates; 3) Functionalized Acetylenic Substrates; 4) Functionalized Halides; 5) Conclusions and Future Perspectives.

Keywords

carbonylation; cyclization; double cyclization; fused heterocycles; heterocyclization; heterocycles; homogeneous catalysis; metal-catalyzed reactions; palladium; polycyclic heterocycles

Subject

Chemistry and Materials Science, Organic Chemistry

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