Version 1
: Received: 25 May 2023 / Approved: 29 May 2023 / Online: 29 May 2023 (02:38:16 CEST)
How to cite:
Шемарова, И.В. Dysfunction of Ca2+ Channels in Hereditary and Chronic Cardiovascular Diseases. Preprints2023, 2023051947. https://doi.org/10.20944/preprints202305.1947.v1
Шемарова, И.В. Dysfunction of Ca2+ Channels in Hereditary and Chronic Cardiovascular Diseases. Preprints 2023, 2023051947. https://doi.org/10.20944/preprints202305.1947.v1
Шемарова, И.В. Dysfunction of Ca2+ Channels in Hereditary and Chronic Cardiovascular Diseases. Preprints2023, 2023051947. https://doi.org/10.20944/preprints202305.1947.v1
APA Style
Шемарова, И.В. (2023). Dysfunction of Ca2+ Channels in Hereditary and Chronic Cardiovascular Diseases. Preprints. https://doi.org/10.20944/preprints202305.1947.v1
Chicago/Turabian Style
Шемарова, И.В. 2023 "Dysfunction of Ca2+ Channels in Hereditary and Chronic Cardiovascular Diseases" Preprints. https://doi.org/10.20944/preprints202305.1947.v1
Abstract
Cardiovascular diseases (CVD) account for about 17.3 million annual deaths worldwide. 85% of these deaths occurred as a result of myocardial infarction (MI) and stroke. Chronic heart diseases, such as arterial hypertension (AH), coronary heart disease, various cerebrovascular diseases, dilated and hypertrophic cardiomyopathies are widespread, with a fairly high incidence of mortality and disability. Most of these diseases are characterized by cardiac arrhythmias, conduction and contractility disorders. Additionally, interruption of the electrical activity of the heart, the appearance of extensive ectopic foci and heart failure are all symptoms of a number of severe hereditary diseases.
The molecular mechanisms leading to the development of CVD are associated with impaired permeability and excitability of cell membranes and mainly caused by dysfunction of cardiac Ca2+ channels.
Acquired channelopathies are caused by metabolic disorders, increased tone of the sympathetic nervous system, age-related changes that lead to deterioration of coronary blood flow and hemodynamics. Currently known channelopathies, such as the long or short QT syndromes, Brugada and Lenegre syndromes, catecholaminergic polymorphic ventricular tachycardia, etc., are congenital and genetic disorders caused by mutations of genes "responsible" for the conductive properties of certain channel-forming proteins, including pore-forming subunits of Ca2+ channels.
Over the past 50 years, more than 100 varieties of ion channels have been found in the cardiovascular system cells. The relationship between the activity of these channels and cardiac pathology, as well as the general cellular biological function, has been intensively studied on several cell types and experimental animal models in vivo и in situ.
In this review, we discuss the origin of Ca2+ channelopathies and the role of Ca2+ channels of various types: L- R-, T-types voltage-gated calcium channels, RyR2, non-selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, transient receptor potential (TRPC, TRPM7, TRPA1) channels in the development of cardio-vascular pathology.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
