Abd Aziz, N.A.; Awang, N.; Chan, K.M.; Kamaludin, N.F.; Mohamad Anuar, N.N. Organotin (IV) Dithiocarbamate Compounds as Anticancer Agents: A Review of Syntheses and Cytotoxicity Studies. Molecules2023, 28, 5841.
Abd Aziz, N.A.; Awang, N.; Chan, K.M.; Kamaludin, N.F.; Mohamad Anuar, N.N. Organotin (IV) Dithiocarbamate Compounds as Anticancer Agents: A Review of Syntheses and Cytotoxicity Studies. Molecules 2023, 28, 5841.
Abd Aziz, N.A.; Awang, N.; Chan, K.M.; Kamaludin, N.F.; Mohamad Anuar, N.N. Organotin (IV) Dithiocarbamate Compounds as Anticancer Agents: A Review of Syntheses and Cytotoxicity Studies. Molecules2023, 28, 5841.
Abd Aziz, N.A.; Awang, N.; Chan, K.M.; Kamaludin, N.F.; Mohamad Anuar, N.N. Organotin (IV) Dithiocarbamate Compounds as Anticancer Agents: A Review of Syntheses and Cytotoxicity Studies. Molecules 2023, 28, 5841.
Abstract
After Frankland first synthesized organotin compounds for the first time in 1849, their broad range of applications, including in industry and agriculture, resulted in a substantial increase in demand for organotin (IV) compounds after the 1940s. Because of the broad range of coordination numbers and molecular geometry that could result in numerous features, the structural diversity of organotin (IV) compounds is of great interest. Organotin (IV) dithiocarbamate has recently received attention as a therapeutic agent among organotin (IV) compounds. The hybrid complex individual properties of organotin (IV) and the dithiocarbamate moieties form a synergy of action stimulating increased biological activity. Organotin (IV) components have been shown in cytotoxicity studies to play a crucial role in cytotoxicity. Ligands serve to target and react to molecules while preventing unwanted changes in biomolecules. Organotin (IV) dithiocarbamate compounds have also been discovered to exhibit a broad range of cellular, biochemical, and molecular effects, with their toxicity largely determined by their structure. This review discusses the potential cytotoxicity effect of organotin(IV) dithiocarbamate, as well as its synthesis, elemental and spectroscopy analysis.
Chemistry and Materials Science, Inorganic and Nuclear Chemistry
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