Version 1
: Received: 25 May 2023 / Approved: 26 May 2023 / Online: 26 May 2023 (09:51:15 CEST)
Version 2
: Received: 26 May 2023 / Approved: 31 May 2023 / Online: 31 May 2023 (08:46:42 CEST)
How to cite:
Malherbe, V.; Celen, S.; Carkeek³, K.; Carapancea, E.; Auriti, C.; Piersigilli, F. Congenital Cytomegalovirus (cCMV) From Non-Primary Maternal Infection: Still a Problem?. Preprints2023, 2023051906. https://doi.org/10.20944/preprints202305.1906.v1
Malherbe, V.; Celen, S.; Carkeek³, K.; Carapancea, E.; Auriti, C.; Piersigilli, F. Congenital Cytomegalovirus (cCMV) From Non-Primary Maternal Infection: Still a Problem?. Preprints 2023, 2023051906. https://doi.org/10.20944/preprints202305.1906.v1
Malherbe, V.; Celen, S.; Carkeek³, K.; Carapancea, E.; Auriti, C.; Piersigilli, F. Congenital Cytomegalovirus (cCMV) From Non-Primary Maternal Infection: Still a Problem?. Preprints2023, 2023051906. https://doi.org/10.20944/preprints202305.1906.v1
APA Style
Malherbe, V., Celen, S., Carkeek³, K., Carapancea, E., Auriti, C., & Piersigilli, F. (2023). Congenital Cytomegalovirus (cCMV) From Non-Primary Maternal Infection: Still a Problem?. Preprints. https://doi.org/10.20944/preprints202305.1906.v1
Chicago/Turabian Style
Malherbe, V., Cinzia Auriti and Fiammetta Piersigilli. 2023 "Congenital Cytomegalovirus (cCMV) From Non-Primary Maternal Infection: Still a Problem?" Preprints. https://doi.org/10.20944/preprints202305.1906.v1
Abstract
Congenital cytomegalovirus (cCMV) infection resulting from non-primary maternal infection or reactivation during pregnancy can cause serious fetal-neonatal sequelae. We describe a male newborn born at term, with signs of perinatal asphyxia, and intractable acute provoked seizures, in the context of severe cCMV infection.
The newborn was delivered in a referral hospital by emergency caesarean section due to fetal distress. Due to signs of asphyxia at birth and clinical moderate encephalopathy (Sarnat 2), he was transferred to our center for therapeutic hypothermia. Continuous full video-electroencephalography monitoring showed no seizures during the first 72 hours, however, soon after rewarming, he presented refractory status epilepticus. Cranial ultrasonography revealed bilateral ventricular and intraparenchymal hemorrhage. Routine infectious screen-ing on urine, blood, cerebrospinal fluid, and nasopharyngeal secretions revealed positive CMV DNA Polymer-ase Chain Reaction (PCR) on all samples. The CMV DNA performed on the bloodspot (Guthrie) card taken at birth yielded a positive result, confirming the intrauterine transmission and congenital origin of the infection.
Maternal non-primary CMV infection in pregnancy is transmitted to the fetus in 0.5-2% of cases. When transmitted, it may cause serious fetal abnormalities, complications in the immediate neonatal period, and se-vere sequelae later in childhood. During pregnancy, it is useful to monitor maternal serology for CMV, even in previously immunized mothers, to identify signs of new infection or viral reactivation and implement measures to prevent neonatal sequelae.
The possible advantages of standardized CMV screening of all newborns are a pertinent discussion point, as this may enable us to identify affected neonates timeously and prevent long term disabilities.
Keywords
Congenital cytomegalovirus; hypothermia; status epilepticus; universal screening
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
*
