Version 1
: Received: 25 May 2023 / Approved: 25 May 2023 / Online: 25 May 2023 (14:36:37 CEST)
How to cite:
Chantiri, M.; Zeinoun, T. Investigate the Effect of rh-BMP2 on the Healing Process of the Gingival Tissue using Ki-67 Marker. Preprints2023, 2023051813. https://doi.org/10.20944/preprints202305.1813.v1
Chantiri, M.; Zeinoun, T. Investigate the Effect of rh-BMP2 on the Healing Process of the Gingival Tissue using Ki-67 Marker. Preprints 2023, 2023051813. https://doi.org/10.20944/preprints202305.1813.v1
Chantiri, M.; Zeinoun, T. Investigate the Effect of rh-BMP2 on the Healing Process of the Gingival Tissue using Ki-67 Marker. Preprints2023, 2023051813. https://doi.org/10.20944/preprints202305.1813.v1
APA Style
Chantiri, M., & Zeinoun, T. (2023). Investigate the Effect of rh-BMP2 on the Healing Process of the Gingival Tissue using Ki-67 Marker. Preprints. https://doi.org/10.20944/preprints202305.1813.v1
Chicago/Turabian Style
Chantiri, M. and Toni Zeinoun. 2023 "Investigate the Effect of rh-BMP2 on the Healing Process of the Gingival Tissue using Ki-67 Marker" Preprints. https://doi.org/10.20944/preprints202305.1813.v1
Abstract
Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-β superfamily, regulate many cellular activities including proliferation and neovascularization. The use of recombinant human bone morphogenic protein 2 (rh-BMP 2) in oral and maxillofacial surgery has seen a tremendous increase, especially with bone grafting materials to promote bone reconstruction processes; even though its interactions with the other essential processes in the human tissues are still not fully clear. investigating the effect of administrating rh-bmp2 on the clinical values of the gingival cell proliferation index Ki67 marker expression in the gingival tissue in comparison with normal human gingival tissue. The study includes 2 groups in a randomized controlled Clinical Trial: 40 gingival samples; 20 normal and 20 have been treated with 0.25µg of rh-BMP2 during dental implantation in the posterior mandible area, taken 3 months later in the time of healing abutments installation using a tissue puncher. Samples will be stained with hematoxylin-eosin and immunohistochemically. The expression of Ki67 will be measured in one way: the number of cells that express the marker. The comparison between groups will be done using One -a way ANOVA test in the numerical data SPSS 17.0 will be used as software. Differences would be considered significant at P=0.05. It is considered that rh-BMP2 can improve gingival tissue proliferation in patients undergoing dental implant treatment, and indicates better healing.
Keywords
rh-BMP2; Ki67-Proliferation – Gingival Tissue
Subject
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
