Version 1
: Received: 22 May 2023 / Approved: 24 May 2023 / Online: 24 May 2023 (02:50:56 CEST)
How to cite:
Ripa, J.D.; Roy, R. Microglia Mediated Neuroinflammation: A Silent Contributor to Alzheimer’s Disease. Preprints2023, 2023051673. https://doi.org/10.20944/preprints202305.1673.v1
Ripa, J.D.; Roy, R. Microglia Mediated Neuroinflammation: A Silent Contributor to Alzheimer’s Disease. Preprints 2023, 2023051673. https://doi.org/10.20944/preprints202305.1673.v1
Ripa, J.D.; Roy, R. Microglia Mediated Neuroinflammation: A Silent Contributor to Alzheimer’s Disease. Preprints2023, 2023051673. https://doi.org/10.20944/preprints202305.1673.v1
APA Style
Ripa, J.D., & Roy, R. (2023). Microglia Mediated Neuroinflammation: A Silent Contributor to Alzheimer’s Disease. Preprints. https://doi.org/10.20944/preprints202305.1673.v1
Chicago/Turabian Style
Ripa, J.D. and Ranjan Roy. 2023 "Microglia Mediated Neuroinflammation: A Silent Contributor to Alzheimer’s Disease" Preprints. https://doi.org/10.20944/preprints202305.1673.v1
Abstract
Microglia together with other permanent macrophages in central nervous system (CNS) are responsible for regulating the innate immune response of the brain and spinal cord. Upon activation, microglia triggers the release of inflammatory mediators such as cytokines, chemokines, and other proteins related to neuro-inflammation. Elevated levels of neuro-inflammation have been linked to a decline in cognitive performance manifested in Alzheimer’s Disease (AD). There are mounting evidence in the literature to suggest that microglia are responsible for a substantial amount of the synaptic damage seen in AD. Most importantly, scientific studies have suggested that overexpression of microglia-derived neuro-inflammation elevates amyloid beta (Aβ) plaque formation, and hyperactivation of tau protein; the two main pathological characteristic features of AD. Alternatively, Aβ and tau formation further activate microglia to sustain the neuro-inflammation triggering a vicious cascade of neurodegeneration in AD. Here in this review, we discussed the role of microglia associated neuroinflammation for the pathogenesis of AD.
Keywords
Microglia; Neuroinflammation; Alzheimer’s Disease
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
