Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evolution of Collective Sars-Cov-2 Humoral Immunity among the Population of the Republic of Belarus

Anna Y. Popova
,
Viacheslav Smirnov
* ORCID logo ,
Svetlana A. Egorova
,
Alexander A. Tarasenko
,
Alla M. Dashkevich
,
Angelika M. Milichkima
,
Angela L. Scuranovich
,
Irina V. Drozd
,
Iruna N. Glinskaya
,
Elena V. Zueva
,
Elena O. Samoilovich
,
Valery A. Ivanov
,
Edward S. Ramsay
,
Alexandra V. Gubanova
,
Victoria G. Drobyshevskaya
,
Oyuna B. Zhumbaeva
,
Olga A. Petrova
,
Alexandra P. Razumovskaya
,
Inna A. Karaban
,
Tamara V. Amvrosieva
,
Natalya P. Shmeleva
,
Ludmila V. Rubanic
,
Alina M. Dronina
,
Areg A. Totolian
ORCID logo
Version 1 : Received: 21 May 2023 / Approved: 23 May 2023 / Online: 23 May 2023 (02:47:10 CEST)

How to cite: Popova, A.Y.; Smirnov, V.; Egorova, S.A.; Tarasenko, A.A.; Dashkevich, A.M.; Milichkima, A.M.; Scuranovich, A.L.; Drozd, I.V.; Glinskaya, I.N.; Zueva, E.V.; Samoilovich, E.O.; Ivanov, V.A.; Ramsay, E.S.; Gubanova, A.V.; Drobyshevskaya, V.G.; Zhumbaeva, O.B.; Petrova, O.A.; Razumovskaya, A.P.; Karaban, I.A.; Amvrosieva, T.V.; Shmeleva, N.P.; Rubanic, L.V.; Dronina, A.M.; Totolian, A.A. Evolution of Collective Sars-Cov-2 Humoral Immunity among the Population of the Republic of Belarus. Preprints 2023, 2023051536. https://doi.org/10.20944/preprints202305.1536.v1 Popova, A.Y.; Smirnov, V.; Egorova, S.A.; Tarasenko, A.A.; Dashkevich, A.M.; Milichkima, A.M.; Scuranovich, A.L.; Drozd, I.V.; Glinskaya, I.N.; Zueva, E.V.; Samoilovich, E.O.; Ivanov, V.A.; Ramsay, E.S.; Gubanova, A.V.; Drobyshevskaya, V.G.; Zhumbaeva, O.B.; Petrova, O.A.; Razumovskaya, A.P.; Karaban, I.A.; Amvrosieva, T.V.; Shmeleva, N.P.; Rubanic, L.V.; Dronina, A.M.; Totolian, A.A. Evolution of Collective Sars-Cov-2 Humoral Immunity among the Population of the Republic of Belarus. Preprints 2023, 2023051536. https://doi.org/10.20944/preprints202305.1536.v1

Abstract

Background. The course of the COVID-19 epidemic process depends on population immunity which prevents pathogen spread among the population. Aim: to study the evolution of SARS-CoV-2 humoral immunity in the Belarusian population relative to COVID-19 pandemic dynamics. Materials and methods. The work was carried out according to a methodology for assessing population immunity developed by Rospotrebnadzor (Russia) and the Belarusian Ministry of Health with the participation of the St. Petersburg Pasteur Institute (SPPI), taking into account WHO recommendations. The study was approved by the Bioethics Committee of Belarus and the SPPI Bioethics Committee. Participant selection was carried out by questionnaire using a cloud (internet server) service. To monitor population immunity, a cohort of 4,661 people (participating in all stages of seromonitoring) was formed from the overall volunteer group. Volunteers were randomized by age group (1-17, 18-29, 30-39, 40-49, 50-59, 60-69, 70+ years), region, and professional group. For the detection of antibodies (Abs) to nucleocapsid (Nc) and S glycoprotein receptor-binding domain (RBD), corresponding assay systems were used following manufacturer instructions. The study was conducted in 4 stages according to a single scheme. Results. In the 1st stage (pandemic month 15), collective immunity was due mainly to Nc+RBD+ Ab status alone. By the 2nd stage (carried out after 4 months), their share decreased 1.2-fold, while the share of volunteers who had only RBD Abs increased 1.7-fold. In the 3rd and 4th stages (carried out after 9 and 19 months), the share of persons with RBD+Nc‒ compared to the 2nd stage decreased by 3.5%; the proportion of persons with Nc+RBD‒ Abs increased by 1.5-fold. The most important factor in population immunity was vaccination of the population, the coverage of which reached 70% by the 4th stage. Among vaccines, the Sputnik V and Sputnik Light vector designs were used most often. The whole-virion, inactivated BIBP-CorV vaccine was used less often. Conclusion. The evolution of collective SARS-CoV-2 humoral immunity included a set of changes in circulating Ab levels (Nc, RBD). The hybrid immunity formed helped to reduce the incidence to nearly zero.

Keywords

Republic of Belarus; population; SARS-CoV-2; COVID-19; seromonitoring; herd immunity; antibodies; nucleocapsid; receptor binding domain; vaccination; hybrid immunity

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.