PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder?
Version 1
: Received: 18 May 2023 / Approved: 19 May 2023 / Online: 19 May 2023 (07:42:29 CEST)
How to cite:
Zhang, H.; Lim, A.; Kang, Z.; Donnelly, E.D.; Ma, L.; Chang, E.L. Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder?. Preprints2023, 2023051397. https://doi.org/10.20944/preprints202305.1397.v1
Zhang, H.; Lim, A.; Kang, Z.; Donnelly, E.D.; Ma, L.; Chang, E.L. Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder?. Preprints 2023, 2023051397. https://doi.org/10.20944/preprints202305.1397.v1
Zhang, H.; Lim, A.; Kang, Z.; Donnelly, E.D.; Ma, L.; Chang, E.L. Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder?. Preprints2023, 2023051397. https://doi.org/10.20944/preprints202305.1397.v1
APA Style
Zhang, H., Lim, A., Kang, Z., Donnelly, E.D., Ma, L., & Chang, E.L. (2023). Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder?. Preprints. https://doi.org/10.20944/preprints202305.1397.v1
Chicago/Turabian Style
Zhang, H., Lijun Ma and Eric L. Chang. 2023 "Treating Cylindrically Populated Endometrial Cancers With High Dose Rate Vaginal Cuff Brachytherapy: Should We Use a MulTi-Channel or Single-Channel Cylinder?" Preprints. https://doi.org/10.20944/preprints202305.1397.v1
Abstract
Purpose: The purpose of this study was to evaluate the dosimetric impact of multiple channels compared to a single channel in high dose rate (HDR) vaginal cuff brachytherapy (VCBT).
Methods and materials: Sample plans of HDR VCBT from both single and multiple channel cylinders at 2.5, 3.0 and 3.5 cm in diameter were created and analyzed. The doses were prescribed either at the 0.5 cm depth with 5.5 Gy for 4 fractions or at the cylinder surface with 8.8 Gy for 4 frac¬tions, in various treatment lengths ranging from 3 to 8 cm. A 0.5 cm ring target volume called PTV_Eval was contoured for each plan and served as the target volume for dosimetric evaluation. Mean doses and the doses covering 90% (D90), 10% (D10), and 5% (D5) of PTV_Eval were calculated and compared. The same treatment lengths, same prescription regimens, same target volume contouring and same plan evaluation methods were repeated for the similar size single channel and multiple channel cylinders.
Results: The mean doses of both regimens with the multi-channel cases (6.3 to 7.1 Gy) were comparable to single channel ones (6.4 and 7.5 Gy). The ranges of D90, D10 and D5 were from 3.654 to 5.04 Gy, 8.44 to 10.08 Gy and 8.84 to 10.86 Gy in the multi-channel cases, but from 5.36 to 5.76 Gy, 7.40 to 9.97 Gy and 8.16 to 11.93 Gy in the single channel cases, respectively.
Conclusion: The single channel and multiple-channel cylinder deliver a similar mean dose, but with marked heterogeneity in D90, D5 and D10 for the same prescription dose and target volume. Multi-channel cylinders adequately cover the target volume, but given the heterogeneity, increased treatment time and cost are best suited for asymmetric target volumes.
Keywords
high dose rate brachytherapy; vaginal cuff brachytherapy; single channel cylinder; multiple channel cylinder, endometrial cancer.
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
