Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Systematic Review and Meta-Analysis of Aortic Morphological Changes after Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury

The first two authors equally contributed to the manuscript and are to be considered co-first authors.
Version 1 : Received: 16 May 2023 / Approved: 17 May 2023 / Online: 17 May 2023 (10:55:23 CEST)

How to cite: Righini, P.; Avishay, D.; Mazzaccaro, D.; Galliagani, M.; Nano, G. A Systematic Review and Meta-Analysis of Aortic Morphological Changes after Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury. Preprints 2023, 2023051241. https://doi.org/10.20944/preprints202305.1241.v1 Righini, P.; Avishay, D.; Mazzaccaro, D.; Galliagani, M.; Nano, G. A Systematic Review and Meta-Analysis of Aortic Morphological Changes after Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury. Preprints 2023, 2023051241. https://doi.org/10.20944/preprints202305.1241.v1

Abstract

Background: Thoracic endovascular aortic repair (TEVAR) has become the standard treatment for blunt thoracic aortic injury (BTAI). Some small observational studies revealed aortic morphological changes after TEVAR in patients with BTAI. However, these studies were limited by the rarity of the condition and small sample sizes. To address this gap, the current study aims to conduct a systematic review and meta-analysis of existing literature to provide evidence on the degree of immediate and long-term aortic diameter change following TEVAR for BTAI. Methods: This systematic review and meta-analysis of studies published up to March 2023, was conducted in accordance with the PRISMA statement. Studies eligible for inclusion were studies evaluating aortic diameter change post-TEVAR in BTAI patients. Results: 14 articles, including 353 patients, were included after review. Treatment and measurement protocols varied among individual studies resulting in high heterogeneity of the results. Our meta-analysis demonstrated an immediate post-intervention dilation 2.41 mm and 2.63 mm of the proximal and distal aortic necks’, respectively, as well as continuous dilation of the respective regions at a rate of 0.35 mm/year and 0.49 mm/year. Conclusion: TEVAR in BTAI leads to immediate post-intervention and continuous aortic dilation and morphological changes with possible future important clinical consequences.

Keywords

Blunt thoracic aortic injury; Thoracic endovascular aortic repair; Thoracic aortic sizing; Systematic review; aortic diameters; Endovascular aortic repair; Thoracic aorta imaging

Subject

Medicine and Pharmacology, Surgery

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