Arai, I.; Tsuji, M.; Takahashi, K.; Saito, S.; Takeda, H. Analyzing the Antinociceptive Effect of Interleukin-31 in Mice. Int. J. Mol. Sci.2023, 24, 11563.
Arai, I.; Tsuji, M.; Takahashi, K.; Saito, S.; Takeda, H. Analyzing the Antinociceptive Effect of Interleukin-31 in Mice. Int. J. Mol. Sci. 2023, 24, 11563.
Arai, I.; Tsuji, M.; Takahashi, K.; Saito, S.; Takeda, H. Analyzing the Antinociceptive Effect of Interleukin-31 in Mice. Int. J. Mol. Sci.2023, 24, 11563.
Arai, I.; Tsuji, M.; Takahashi, K.; Saito, S.; Takeda, H. Analyzing the Antinociceptive Effect of Interleukin-31 in Mice. Int. J. Mol. Sci. 2023, 24, 11563.
Abstract
The theory that an itch inhibits pain has been refuted; however, previous research did not investigate this theory for interleukin-31 (IL-31)-induced itch. Previously, we have found that morphine-induced antinociception was partially reduced in IL-31 receptor A (IL-31RA)-deficient (IL-31RAKI) mice, indicating that IL-31RA may play an important role in morphine-induced peripheral antinociception. In the present study, we evaluated the effect of IL-31-induced analgesia on a 2,4,6-trinitrochlorobenzene (TNCB)-sensitized mice using a hot-plate test. This test evaluated the antinociceptive activity of morphine, and non-steroidal anti-inflammatory drugs (NSAIDs). Repeated pretreatment with IL-31 showed significant antinociceptive action. Furthermore, its combination with morphine, but not with NSAIDs, increased the analgesic action. In contrast, treatment with TNCB and capsaicin decreased antinociception. Moreover, TNCB increased IL-31RA expression in the dorsal root ganglia at 24 h, whereas capsaicin inhibited it. The comparative action of several analgesics on TNCB or capsaicin was evaluated using a hot-plate test, which revealed that the antinociceptive activity was decreased or disappeared in response to capsaicin-induced pain and in IL-31RAKI mice. These results indicate that the analgesic action of IL-31 involves the peripheral nervous system, which affects sensory nerve. These results provide a basis for developing novel analgesics using this mechanism.
Keywords
analgesia; alloknesis; antinociception; interleukin-31 (IL-31); interleukin receptor A (IL-31RA); IL-31 receptor A deficient (IL-31RAKI) mice; itch; pain.
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
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