PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Leukotrienes E4 and B4 and Vascular Endothelium – New Insight into the Link between Vascular Inflammation and Peripheral Arterial Disease and Its Complications
Version 1
: Received: 7 May 2023 / Approved: 8 May 2023 / Online: 8 May 2023 (11:05:28 CEST)
How to cite:
Wachsmann-Maga, A.; Włodarczyk, A.; Maga, M.; Batko, K.; Bogucka, K.; Kapusta, M.; Terlecki, P.; Maga, P. Leukotrienes E4 and B4 and Vascular Endothelium – New Insight into the Link between Vascular Inflammation and Peripheral Arterial Disease and Its Complications. Preprints2023, 2023050532. https://doi.org/10.20944/preprints202305.0532.v1
Wachsmann-Maga, A.; Włodarczyk, A.; Maga, M.; Batko, K.; Bogucka, K.; Kapusta, M.; Terlecki, P.; Maga, P. Leukotrienes E4 and B4 and Vascular Endothelium – New Insight into the Link between Vascular Inflammation and Peripheral Arterial Disease and Its Complications. Preprints 2023, 2023050532. https://doi.org/10.20944/preprints202305.0532.v1
Wachsmann-Maga, A.; Włodarczyk, A.; Maga, M.; Batko, K.; Bogucka, K.; Kapusta, M.; Terlecki, P.; Maga, P. Leukotrienes E4 and B4 and Vascular Endothelium – New Insight into the Link between Vascular Inflammation and Peripheral Arterial Disease and Its Complications. Preprints2023, 2023050532. https://doi.org/10.20944/preprints202305.0532.v1
APA Style
Wachsmann-Maga, A., Włodarczyk, A., Maga, M., Batko, K., Bogucka, K., Kapusta, M., Terlecki, P., & Maga, P. (2023). Leukotrienes E4 and B4 and Vascular Endothelium – New Insight into the Link between Vascular Inflammation and Peripheral Arterial Disease and Its Complications. Preprints. https://doi.org/10.20944/preprints202305.0532.v1
Chicago/Turabian Style
Wachsmann-Maga, A., Piotr Terlecki and Paweł Maga. 2023 "Leukotrienes E4 and B4 and Vascular Endothelium – New Insight into the Link between Vascular Inflammation and Peripheral Arterial Disease and Its Complications" Preprints. https://doi.org/10.20944/preprints202305.0532.v1
Abstract
Leukotrienes are proinflammatory mediators that participate in the process of atherogenesis and contribute to the development of symptomatic peripheral arterial disease. The aim was to evaluate the relationship between leukotriene E4 (LTE4) and B4 (LTB4) with parameters reflecting endothelial vascular function in patients with chronic lower limb ischemia. This prospective observational study enrolled 50 consecutive patients undergoing endovascular treatment due to chronic lower limb ischemia (Rutherford 3). All participants were followed-up for one year (after 1, 3, 6 and 12 months), with a sequential assessment of urinary LTE4 and LTB4, as well as measures of endothelial and vascular function: Flow-Mediated Dilatation (FMD), Intima-Media Thickness (IMT), corrected Augmentation Index (AI75), Shear Rate (SR), Ankle-Brachial Index (ABI), Toe-Brachial Index (TBI). There was a significant relationship between LTE4 and measures of vascular function: FMD (R2 = 0.69, P<0.001), IMT (R2=0.12, P<0.01), AI75 (R2=0.43, P<0.001), SR (R2=0.48, P<0.001). Similar findings were noted for LTB4: FMD (R2=0.47, p<0.001), IMT (R2=0.23, P<0.001), AI75 (R2=0.61, P<0.001) and SR (R2=0.33, P<0.001). Alterations in parameters were significantly related: ΔLTE4 vs ΔFMD(R2=0.63, P<0.001), ΔSR (R2=0.42, P<0.001) and ΔLTB4 vs AI75(R2=0.40, P<0.001), SR(R2=0. 29, P<0.001). We conclude, that increasing concentrations of LTE4 and LTB4 are associated with impairment of vascular and endothelial function, which may lead to worse endovascular treatment clinical outcomes.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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