Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Influence of HIV/AIDS infection on Immunological and Nutritional Status. A Cross Sectional Study in Kingdom of Bahrain

Version 1 : Received: 6 May 2023 / Approved: 8 May 2023 / Online: 8 May 2023 (10:10:36 CEST)

How to cite: Alabdulali, F.; Freije, A.; Al-Mannai, M.; Alsalman, J.; Buabbas, F.; Rondanelli, M.; Perna, S. Influence of HIV/AIDS infection on Immunological and Nutritional Status. A Cross Sectional Study in Kingdom of Bahrain. Preprints 2023, 2023050504. https://doi.org/10.20944/preprints202305.0504.v1 Alabdulali, F.; Freije, A.; Al-Mannai, M.; Alsalman, J.; Buabbas, F.; Rondanelli, M.; Perna, S. Influence of HIV/AIDS infection on Immunological and Nutritional Status. A Cross Sectional Study in Kingdom of Bahrain. Preprints 2023, 2023050504. https://doi.org/10.20944/preprints202305.0504.v1

Abstract

Background and Objectives: HIV infection is a global public health problem that can lead to the progression of AIDS. Nutritional status and biochemical markers can significantly contribute to the progression of AIDS in HIV/AIDS patients. The main objective of this study is to examine the association between the nutritional and biochemical markers as well as BMI in HIV/AIDS patients in the kingdom of Bahrain. Methods: A retrospective cohort study, including 300 patients (248 males and 52 females) with HIV/AIDS in Bahrain. Various biochemical markers were collected from patients’ medical records including CD4^+ T cells counts, albumin, Hb, HCT, MCV, WBC, and creatinine. A semi-structured questionnaire using of a standardized food frequency questionnaire (FFQ) was used from which total energy and total macronutrients were calculate. Results: the mean BMI of participants was 27.20 kg/m2 with none of the participants had a BMI lower than 18.5 kg/m2 (underweight). The majority of patients’ dietary intake of macronutrients and total calories intake were either within or above the recommended RDA levels. The results also showed that all mean values of the nutritional and biochemical markers (CD4^+ T cells counts, albumin, Hb, HCT, MCV, WBC, and creatinine) are within the referenced normal ranges. A significant positive correlation of CD4^+ T cells counts, Hb, HCT and albumin at <0.05 level was found. There was no significant correlation between CD4^+ T cells counts and MCV, WBC and creatinine. A positive significant correlation was found between BMI, CD4^+ T cells counts, and WBC at <0.01 level. Conclusion: BMI values significantly correlated to biochemical markers of AIDS progression. Dietary pattern of participants was undiversified among participants, with high prevalence of obesity and overweight. Malnutrition among this study population was not present.

Keywords

HIV/AIDS patients; Nutritional; biochemical; Markers; immunological disease

Subject

Biology and Life Sciences, Virology

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